Details of First Three-Parent IVF Revealed

The team that oversaw the first use of mitochondrial replacement therapy that resulted in a live birth has published an account of the procedure.

Written byBob Grant
| 2 min read

Register for free to listen to this article
Listen with Speechify
0:00
2:00
Share

John Zhang with the baby that was the first ever to be born after mitochondrial replacement therapyIMAGE COURTESY OF NEW HOPE FERTILITY CLINIC

Last year, a Jordanian couple became parents to the world’s first-ever baby born through a controversial in vitro fertilization (IVF) technique called mitochondrial replacement therapy (MRT). Now, the doctors who performed the procedure, which involves inserting nuclei from the mothers’ egg cells and into donor ova with healthy mitochondria, have revealed more detail on the conception and resulting live birth.

John Zhang of the New Hope Fertility Center in New York City and colleagues published an account of the treatment in this month’s issue of Reproductive BioMedicine Online. “Certainly, this is a landmark study,” Dietrich Egli, a stem cell researcher at the New York Stem Cell Foundation, told Nature.

Zhang and colleagues revealed that the mother of the baby boy is a carrier of Lehigh ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!
Already a member? Login Here

Related Topics

Meet the Author

  • From 2017 to 2022, Bob Grant was Editor in Chief of The Scientist, where he started in 2007 as a Staff Writer. Before joining the team, he worked as a reporter at Audubon and earned a master’s degree in science journalism from New York University. In his previous life, he pursued a career in science, getting a bachelor’s degree in wildlife biology from Montana State University and a master’s degree in marine biology from the College of Charleston in South Carolina. Bob edited Reading Frames and other sections of the magazine.

    View Full Profile
Share
Illustration of a developing fetus surrounded by a clear fluid with a subtle yellow tinge, representing amniotic fluid.
January 2026, Issue 1

What Is the Amniotic Fluid Composed of?

The liquid world of fetal development provides a rich source of nutrition and protection tailored to meet the needs of the growing fetus.

View this Issue
Skip the Wait for Protein Stability Data with Aunty

Skip the Wait for Protein Stability Data with Aunty

Unchained Labs
Graphic of three DNA helices in various colors

An Automated DNA-to-Data Framework for Production-Scale Sequencing

illumina
Exploring Cellular Organization with Spatial Proteomics

Exploring Cellular Organization with Spatial Proteomics

Abstract illustration of spheres with multiple layers, representing endoderm, ectoderm, and mesoderm derived organoids

Organoid Origins and How to Grow Them

Thermo Fisher Logo

Products

Brandtech Logo

BRANDTECH Scientific Introduces the Transferpette® pro Micropipette: A New Twist on Comfort and Control

Biotium Logo

Biotium Launches GlycoLiner™ Cell Surface Glycoprotein Labeling Kits for Rapid and Selective Cell Surface Imaging

Colorful abstract spiral dot pattern on a black background

Thermo Scientific X and S Series General Purpose Centrifuges

Thermo Fisher Logo
Abstract background with red and blue laser lights

VANTAstar Flexible microplate reader with simplified workflows

BMG LABTECH