Gene Therapy in One Eye Improves Vision in Both Eyes
Gene Therapy in One Eye Improves Vision in Both Eyes
It’s not clear why the patients with Leber hereditary optic neuropathy, a mitochondrial disorder that causes blindness, also experienced the modest benefits in their untreated eye.
Gene Therapy in One Eye Improves Vision in Both Eyes
Gene Therapy in One Eye Improves Vision in Both Eyes

It’s not clear why the patients with Leber hereditary optic neuropathy, a mitochondrial disorder that causes blindness, also experienced the modest benefits in their untreated eye.

It’s not clear why the patients with Leber hereditary optic neuropathy, a mitochondrial disorder that causes blindness, also experienced the modest benefits in their untreated eye.

Mitochondrial disease
Opinion: The Central Dogma of Mitochondrial Genetics Needs Rewriting
John D. Loike | Dec 12, 2018 | 3 min read
The recent discovery of 17 people who have inherited maternal and paternal lines of mitochondrial DNA has major ramifications for medical and ancestry research.
Fathers Can Pass Mitochondrial DNA to Children
Anna Azvolinsky | Dec 4, 2018 | 4 min read
Researchers identify unique cases in which people inherited mitochondrial DNA not just from their mother but also from their father.
Gene Editing Treats Mitochondrial Disorders in Mice
Catherine Offord | Sep 25, 2018 | 2 min read
Researchers used TALENs and zinc finger nucleases to correct disease-causing mutations.
Mitochondrial Isolation System
Ruth Williams | May 1, 2018 | 3 min read
A transgenic approach allows researchers to collect the organelles from specific cells in nematodes with unprecedented efficiency.
Infographic: Isolating mitochondria from specific cell types
Ruth Williams | Apr 30, 2018 | 1 min read
Adding a fusion gene to certain mitochondria in C. elegans enables researchers to collect and analyze them.
Image of the Day: Mitochondria, Live and in Color
The Scientist Staff | Sep 27, 2017 | 1 min read
Mitochondria age differently depending upon whether they’re located in the liver, heart, or kidney, scientists find in flies and mice.
Details of First Three-Parent IVF Revealed
Bob Grant | Apr 3, 2017 | 2 min read
The team that oversaw the first use of mitochondrial replacement therapy that resulted in a live birth has published an account of the procedure.
Opinion: Ethical Considerations of “Three-Parent” Babies
John D. Loike and Nancy Reame | Dec 22, 2016 | 4 min read
Mitochondrial replacement therapy raises important societal and ethical concerns, but should be embraced for its utility in preventing disease.
Three-Parent IVF Advances
Anna Azvolinsky | Nov 30, 2016 | 4 min read
Differences in the replicative advantages conferred by some mitochondrial DNA haplotypes have implications for mitochondrial replacement therapy, researchers report. 
Kids’ Sudden Cardiac Deaths Explained by Heritable Mutations in a Single Gene
Kerry Grens | Aug 11, 2016 | 4 min read
Examining the tragedies of several families who each lost multiple children, two teams of researchers reveal a previously unappreciated role for a mitochondrial enzyme.
Improving Mitochondrial Replacement Therapy
Anna Azvolinsky | Jun 8, 2016 | 3 min read
Pronuclear transfer can reduce the risk of transferring defective mitochondria, a study shows.  
Bill Banning Mitochondrial Replacement Therapy Considered
Tanya Lewis | May 19, 2016 | 1 min read
The US Senate is reviewing a bill that would extend a ban on so-called three-parent embryos.
IOM: Mitochondrial Replacement “Ethically Permissible”
Tracy Vence | Feb 4, 2016 | 2 min read
Experts from the US National Institute of Medicine outline their conditional approval of clinical research on mitochondrial replacement techniques.
Mitochondria Swap
Kate Yandell | Jul 15, 2015 | 3 min read
Researchers generate patient-specific induced pluripotent stem cells corrected for mitochondrial defects.
Opinion: Too Many Mitochondrial Genome Papers
David R. Smith | Jun 29, 2015 | 3 min read
And too few insights gleaned from them
Erasing Mitochondrial Mutations
Jenny Rood | Apr 23, 2015 | 3 min read
Researchers develop a method to selectively remove mutated mitochondrial DNA from the murine germline and single-celled mouse embryos.
Nourishing the Aging Brain
Morten Scheibye-Knudsen | Mar 1, 2015 | 5+ min read
Research reveals how the brain changes as we age and hints at ways to slow the decline.
UK Supports Three-Parent IVF
Jef Akst | Feb 3, 2015 | 1 min read
Parliament today voted to allow techniques that could help couples produce babies with a reduced chance of passing on heritable mitochondrial diseases.
Mutations Pervade Mitochondrial DNA
Jyoti Madhusoodanan | Jul 6, 2014 | 3 min read
Pathogenic mutations in mitochondrial DNA are common in healthy people, according to a new study.