Researchers harness a protein to send cargo-carrying exosomes to mouse muscles.
To treat a mouse model of Duchenne muscular dystrophy, molecules of the exosome-binding peptide CP05 are linked either to the muscle-targeting peptide M12 or an oligomer (PMO) that corrects a splicing error in the gene for dystrophin. These two conjugate peptides paint the surface of exosomes from cultured mouse cells. When injected into the mice, the exosomes home to muscle, where they deliver the oligomer, boost functional dystrophin levels, and improve muscle function.
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Ruth is a freelance journalist. Before freelancing, Ruth was a news editor for the Journal of Cell Biology in New York and an assistant editor for Nature Reviews Neuroscience in London. Prior to that, she was a bona fide pipette-wielding, test tube–shaking, lab coat–shirking research scientist. She has a PhD in genetics from King’s College London, and was a postdoc in stem cell biology at Imperial College London. Today she lives and writes in Connecticut.
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A neurobiologist, who loves the morphology of cells, turns these shapes into works of art made from wood.
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