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A computer simulation of the process of translation, with the ribosome shown in blue/purple, housing a multicolored mRNA and building a protein in red with the help of dark violet tRNAs carrying red amino acids.
The Origins and Recent Promise of Nonsense Suppressor tRNAs
A discovery that goes back to the first studies of translation has become the topic of biotech buzz.
The Origins and Recent Promise of Nonsense Suppressor tRNAs
The Origins and Recent Promise of Nonsense Suppressor tRNAs

A discovery that goes back to the first studies of translation has become the topic of biotech buzz.

A discovery that goes back to the first studies of translation has become the topic of biotech buzz.

gene therapy

A light gray mouse against an orange background listens to tiny headphones
Journey to the Center of the Ear
Niki Spahich, PhD | Aug 28, 2023 | 5 min read
An aqueduct connecting the brain to the ear may make gene therapy for hearing loss less invasive.
MRI images of brains from patients with epilepsy
Defending against Dravet
Aparna Nathan, PhD | Aug 21, 2023 | 3 min read
Gene therapy may be the first step toward curing a rare genetic epilepsy.
Building Bridges podcast logo
Building Bridges for Translational Research - A Special Podcast Series
The Scientist’s Creative Services Team and Cytiva | 2 min read
Translational scientists discuss their experiences taking preclinical concepts to the market.
Patient with skin blisters being swabbed by gloved hand
Delivering Gene Therapies in Utero 
Natalia Mesa, PhD | Jul 18, 2023 | 3 min read
By delivering mRNA to the skin of mice in utero, researchers showed a proof-of-concept for shuttling gene therapies to skin cells before birth.
Learn How Researchers Make the Most of Viral Vectors for Gene Therapy
Viral Vector Platforms for Gene Therapy
The Scientist’s Creative Services Team | Feb 9, 2023 | 1 min read
In both the laboratory and clinic, scientists harness viral genetic transfer capabilities to develop gene therapies that modulate cellular function.
 Learn about analyzing mRNA with direct sequence mapping 
Solutions for mRNA Direct Sequence Mapping
Thermo Fisher Scientific | 1 min read
As mRNA therapeutics gain popularity, a novel solution for their development emerges.
2022 Top 10 Innovations 
2022 Top 10 Innovations
The Scientist Staff | Dec 12, 2022 | 10+ min read
This year’s crop of winning products features many with a clinical focus and others that represent significant advances in sequencing, single-cell analysis, and more.
Building with sign reading “Novartis”
Two Children Die After Receiving Novartis Gene Therapy
Andy Carstens | Aug 12, 2022 | 1 min read
No deaths had previously been associated with the muscle-wasting treatment Zolgensma.
Learn about establishing a Gene Therapy Manufacturing Strategy 
Considerations for Gene Therapy Manufacturing Strategies
Thermo Fisher Scientific | 1 min read
Discover tips for setting up and optimizing adeno-associated virus production.
A white mouse huddles with some of her nine-day-old pups.
In Vivo Gene Therapy Cures Infertility in Mice
Dan Robitzski | May 2, 2022 | 2 min read
Mice rendered infertile through ovary cell–targeting mutations gave birth to seemingly normal offspring through natural mating after a virus-based gene therapy was injected into their ovaries.
3D virus cells attacking a DNA strand
HIV DNA Circularizes to Bypass CRISPR-Based Treatments
Nele Haelterman, PhD | Mar 7, 2022 | 3 min read
CRISPR-mediated removal of HIV can create small, infectious DNA molecules.
Scalable and reproducible solutions in CAR T cell therapy workflows 
Advancing CAR T Cell Research and Development
Bio-Rad | 1 min read
How to develop the best CAR T cell product for preclinical use.
An orange CRISPR Cas 9 enzyme cutting DNA
CRISPR-Based Treatment Successfully Lowers Toxic Protein Levels
Natalia Mesa, PhD | Mar 2, 2022 | 3 min read
A first-of-its-kind gene therapy dramatically reduced misfolded protein levels in some clinical trial participants for up to six months and reduced levels in all participants for up to a year.
DNA
In Editing RNA, Researchers See Endless Possibilities
Christie Wilcox, PhD | Dec 1, 2021 | 10 min read
RNA editing has been in DNA editing’s shadow for nearly a decade, but recent investments in the technology could bring it into the limelight.
Discover the potential of AAV vectors for gene therapy delivery
From Concept to Cure: Using AAV in Gene Therapy
The Scientist’s Creative Services Team and Bio-Rad Laboratories | 1 min read
With the right tools and techniques, researchers develop safe and effective adeno-associated virus (AAV)-based gene therapies.
An artistic rendering of blue neurons against a white background
Participant’s Diagnosis Halts Gene Therapy Clinical Trial
Amanda Heidt | Aug 12, 2021 | 3 min read
The FDA pauses the research program on a lentivirus-based treatment for a rare neurological condition after a patient developed a bone marrow disorder that could presage leukemia.
An illustration of a DNA double helix in gold with texture
Gene Therapy Continues to Benefit Kids with Immunodeficiency
Jef Akst | May 12, 2021 | 2 min read
Four dozen children with severe combined immunodeficiency (SCID) who received a corrective gene carried by a virus have working immune systems two to three years later, according to three independent clinical trials.
Learn How Cutting-Edge Science is Breaking Through Industry Barriers
Focus on Innovation: Scientific Advances Driving Biopharma Market Trends
The Scientist’s Creative Services Team and Tecan | 1 min read
Explore the future of biopharma research and development.
obituary, obituaries, microbiology, molecular genetics, biochemistry, bioinformatics, Stanford University, University of Southern California, cell & molecular biology
Laurence “Larry” Kedes, Molecular Geneticist, Dies at 83
Amanda Heidt | Apr 26, 2021 | 4 min read
In addition to isolating the first protein-coding gene from a eukaryote, Kedes furthered scientists’ understanding of actin genes and also laid the foundations for modern DNA databases such as GenBank.
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