First Antibody Trial Launched in COVID-19 Patients

In record time, scientists have gone from harvesting antibodies against SARS-CoV-2 from survivors of coronavirus infections to testing the antibodies’ safety as a drug in humans.

Written byKatarina Zimmer
| 8 min read
monoclonal antibody antibodies sars-cov-2 covid-19 coronavirus pandemic eli lilly receptor binding domain spike protein

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Thanks to a remarkable feat of natural molecular engineering that allows our bodies to generate countless different kinds of antibodies against pathogens, COVID-19 survivors typically have scads of SARS-CoV-2–specific antibodies cruising through their bloodstreams. Only a few of those antibodies stick to the virus at the right spot, blocking a protein the virus needs to break into cells, while other antibodies bind to it without stopping infection. By the time a human body has generated these diverse antibodies in sufficient quantities, the original infection is usually nearly over, but the antibodies remain, leaving the immune system braced for a second infection.

For the past few months, scientists have been eager to find the most effective antibodies the human body produces and turn them into drugs. In contrast to convalescent plasma therapies—whereby a hodgepodge of antibodies from recovered patients is given to people battling COVID-19—such ...

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Meet the Author

  • katya katarina zimmer

    After a year teaching an algorithm to differentiate between the echolocation calls of different bat species, Katarina decided she was simply too greedy to focus on one field of science and wanted to write about all of them. Following an internship with The Scientist in 2017, she’s been happily freelancing for a number of publications, covering everything from climate change to oncology. Katarina is a news correspondent for The Scientist and contributes occasional features to the magazine. Find her on Twitter @katarinazimmer and read her work on her website.

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