PIXABAY, GERALTBy analyzing the DNA of people who have been insensitive to pain since birth, researchers have homed in on an epigenetic regulator tied to the disorder. Mutations in PRDM12, a gene that appears important for the proper development of sensory neurons, cripple its ability to modify histones, researchers reported in Nature Genetics this week (May 25).
“We are very hopeful that this new gene could be an excellent candidate for drug development, particularly given recent successes with drugs targeting chromatin regulators in human disease,” Ya-Chun Chen from the University of Cambridge who led the work said in a statement.
As The Guardian reported, two other genes, SCN9A and SCN11A, were already associated with congenital insensitivity to pain. Both encode sodium channels. In the latest study, a large group of collaborators analyzed DNA from 11 families with members who have the condition. Among the affected family members, the research team identified 10 different mutations within PRDM12, each of which inhibited proper functioning of the protein. Furthermore, knocking down the gene’s ortholog in frog embryos disrupted neurogenesis during development.
“PRDM12 is essential for ...
