Genetic Variants Linked to Depression

Researchers link variations in two genes to cases of major depressive disorder in two large cohorts.

Written byAmanda B. Keener
| 2 min read

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Researchers have confirmed a genetic link to depression for the first time. Variations in two genes appeared more frequently in a population with major depressive disorder, according to a study published last week (July 15) in Nature.

“This is an important study because it convincingly identifies DNA variations linked to depression for the first time,” Jordan Smoller, a psychiatrist at Harvard University who was not involved in the study told The Verge. “It provides clues to the underlying biology of depression—and perhaps new targets for developing treatments.”

An international group of researchers compared the genome sequences of 5,303 Han Chinese women with recurrent major depressive disorder to those of 5,337 women without depression. The team linked variants of two genes found on chromosome 10 with ...

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