How Immune Cells Make the Brain Forget

Microglia ingest nerve cell connections, leading to the loss of information stored in neuronal circuits.

Written byAshley Yeager
| 5 min read

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ABOVE: MEMORY POLICE: Brain cells called microglia (red) snip connections between nerve cells (blue) in the mouse hippocampus, in a process that may influence forgetting.
© CHAO WANG

Nearly seven years ago, Sheena Josselyn and her husband Paul Frankland were talking with their two-year-old daughter and started to wonder why she could easily remember what happened over the last day or two but couldn’t recall events that had happened a few months before. Josselyn and Frankland, both neuroscientists at the Hospital for Sick Children Research Institute in Toronto, suspected that maybe neurogenesis, the creation of new neurons, could be involved in this sort of forgetfulness.

In humans and other mammals, neurogenesis happens in the hippocampus, a region of the brain involved in learning and memory, tying the generation of new neurons to the process of making memories. Josselyn and Frankland knew that in infancy, the brain makes a lot of new ...

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Meet the Author

  • Ashley started at The Scientist in 2018. Before joining the staff, she worked as a freelance editor and writer, a writer at the Simons Foundation, and a web producer at Science News, among other positions. She holds a bachelor’s degree in journalism from the University of Tennessee, Knoxville, and a master’s degree in science writing from MIT. Ashley edits the Scientist to Watch and Profile sections of the magazine and writes news, features, and other stories for both online and print.

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Published In

May 2020

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The fundamental cognitive process is revealing itself to science

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