Artist’s rendition of multiple <em>Neisseria gonorrhoeae</em>, the bacteria that causes gonorrhea, depicted as two spheres stuck together, each covered in tendrils.
Gonorrhea-Blocking Mutation Also Protects Against Alzheimer’s: Study
Research traces the evolution of a gene variant that reduces the risk of Alzheimer’s disease, finding that it originally evolved in response to infectious bacteria.
Gonorrhea-Blocking Mutation Also Protects Against Alzheimer’s: Study
Gonorrhea-Blocking Mutation Also Protects Against Alzheimer’s: Study

Research traces the evolution of a gene variant that reduces the risk of Alzheimer’s disease, finding that it originally evolved in response to infectious bacteria.

Research traces the evolution of a gene variant that reduces the risk of Alzheimer’s disease, finding that it originally evolved in response to infectious bacteria.

microglia
Illustration of peach-colored microglia among light blue neurons. Both cell types are illustrated with multiple jagged extensions coming out of a spherical cell body.
Mouse Immune Cells Destroy Nerves’ Coating, Causing Chronic Pain
Patience Asanga | Jun 9, 2022

A study suggests a way in which acute nerve injury could trigger an autoimmune response that leads to continuing pain in mice.

Ramified cells in a lilac background
Could Vitamin Supplementation Help Alzheimer’s Patients?
Alejandra Manjarrez | Apr 11, 2022
Niacin, a form of vitamin B3 used to treat cardiovascular disease, helps immune cells in the brain fight neurodegenerative diseases such as Alzheimer’s in mice models, according to recent studies. Researchers hope that human clinical trials will swiftly follow.
Capturing Brain Complexity in Assembloids
Capturing Brain Complexity in Assembloids
The Scientist Creative Services Team
In this webinar, Jimena Anderson and Jens Schwamborn will describe the next-generation brain organoids that combine multiple brain regions and cell types in 3D cultures.
Image of brain cells showing pyramidal neurons in green, astrocytes in red, and microglia in blue
Replacing Microglia Treats Neurodegenerative Disease in Mice
Shawna Williams | Mar 17, 2022
Researchers find a way to wipe out the brain’s immune cell corps and send in new and improved versions.
Translucent, red-orange organs are shown inside a person’s transparent, blue torso. One region zooms in on blue lung alveoli covered by bright orange microbes.
Bacteria in the Lungs Can Regulate Autoimmunity in Rat Brains
Dan Robitzski | Mar 17, 2022
Making specific alterations to the bacterial population in a rat’s lungs either better protects the animals against multiple sclerosis–like symptoms or makes them more vulnerable, a study finds—the first demonstration of a lung-brain axis.
800x560-oct-5-2021
Technique Talk: Live-Cell Imaging Strategies to Quantify Phagocytosis
The Scientist Creative Services Team in collaboration with Sartorius
Discover how to image and quantitate phagocytosis in real time
Artist’s rendering of brain fog: a bright blue drawing of a brain sits inside of a pink drawing of a head in profile surrounded by miscellaneous shapes
Brain Fog Caused by Long COVID and Chemo Appear Similar
Dan Robitzski | Jan 28, 2022
Data from mouse models for mild coronavirus infections and human tissue samples offer further evidence that it doesn’t take a severe infection—or even infection of brain cells at all—to cause long-term neurological symptoms.
Brain cells with electrical firing. 3D rendering.
Microglia as Therapeutic Targets in Neurodegenerative Diseases
Sruthi S. Balakrishnan | Oct 1, 2021
Pharmaceutical companies ramp up efforts to get the brain’s immune cells to help treat Alzheimer’s disease and other conditions, but not everyone agrees the approach will be effective.
LabTalk Podcast - Understanding Microglial Response in Alzheimer’s Disease
The Scientist Creative Services Team and 10x Genomics
Single-cell technologies reveals subpopulations of microglia that play distinct roles in diseased and healthy brains.
One white mouse with red eyes runs on a blue exercise wheel, while another mouse stands with front paws on the wheel
Serious Infections Linked to Autism: Study
Abby Olena | Sep 17, 2021
In both a mouse model and the hospital records of more than 3 million children, researchers found a connection between strong immune activation in males and later symptoms of autism spectrum disorder.
artistic drawing of neuron filled with tau proteins
Genes for Alcohol Use Disorder and Alzheimer’s Risk Overlap: Study
Emma Yasinski | Aug 24, 2021
Genetic, transcriptomic, and epigenetic data reveal molecular mechanisms tying these disorders to each other and to immune disfunction.
Breaking Down Barriers
The Scientist Creative Services Team
Looking at the future of neurodegeneration research!
A microscopy image of a mouse brain that shows the lymphatic system in bright purple and pink
Brain’s Lymphatic System Tied to Alzheimer’s Symptoms in Mice
Amanda Heidt | May 4, 2021
A dysfunctional lymphatic system, described as a clogging of the brain’s sink, may explain why immunotherapies fail in some Alzheimer’s patients.
Study Points to Novel Role for Microglia in Down Syndrome
Catherine Offord | Oct 6, 2020
Overactive immune cells identified in a mouse model and in postmortem human brain tissue may offer a potential therapeutic target for cognitive delays associated with the condition, researchers report.
T Cells and Neurons Talk to Each Other
Ashley Yeager | Oct 1, 2020
Conversations between the immune and central nervous systems are proving to be essential for the healthy social behavior, learning, and memory.
The Brain’s Immune Cells Stand Sentinel Against Viral Invasion
Ashley Yeager | Oct 1, 2020
Some viruses, possibly even SARS-CoV-2, can sneak into the brain through the nose. Recent studies show that microglia are ready for them when they do.
Infographic: How Cytokines Flow into and out of the Brain
Ashley Yeager | Oct 1, 2020
Several routes exist for immune cells to communicate with neurons in the central nervous system, though T cells rarely come in direct contact with neural tissue.
How Immune Cells Make the Brain Forget
Ashley Yeager | May 1, 2020
Microglia ingest nerve cell connections, leading to the loss of information stored in neuronal circuits.
Image of the Day: Memory Erasure
Amy Schleunes | Feb 12, 2020
By trimming synapses in the adult mouse hippocampus, microglia help facilitate forgetting.