In both a mouse model and the hospital records of more than 3 million children, researchers found a connection between strong immune activation in males and later symptoms of autism spectrum disorder.

Genetic, transcriptomic, and epigenetic data reveal molecular mechanisms tying these disorders to each other and to immune disfunction.

A dysfunctional lymphatic system, described as a clogging of the brain’s sink, may explain why immunotherapies fail in some Alzheimer’s patients.

Overactive immune cells identified in a mouse model and in postmortem human brain tissue may offer a potential therapeutic target for cognitive delays associated with the condition, researchers report.

Conversations between the immune and central nervous systems are proving to be essential for the healthy social behavior, learning, and memory.

Some viruses, possibly even SARS-CoV-2, can sneak into the brain through the nose. Recent studies show that microglia are ready for them when they do.

Several routes exist for immune cells to communicate with neurons in the central nervous system, though T cells rarely come in direct contact with neural tissue.

Microglia ingest nerve cell connections, leading to the loss of information stored in neuronal circuits.

By trimming synapses in the adult mouse hippocampus, microglia help facilitate forgetting.

Clues about the biological mechanisms that contribute to a person’s chance of contemplating or attempting suicide

The biochemical mechanisms in the brain underlying suicidal behavior are beginning to come to light, and researchers hope they could one day lead to better treatment and prevention strategies.

Clinical trials that target human endogenous retroviruses to treat multiple sclerosis, ALS, and other ailments are underway, but many questions remain about how these sequences may disrupt our biology.

The brain’s immune cells gobble up synapses in the hippocampi of rodents fed high-fat or high-sugar diets.

A new study reports that immune memory may contribute to neurodegenerative diseases.

Immune-like cells in the central nervous system are now recognized as key participants in the creation and maintenance of persistent pain.

The acute pain that results from injury or disease is very different from chronic pain.