Microglia as Therapeutic Targets in Neurodegenerative Diseases
Microglia as Therapeutic Targets in Neurodegenerative Diseases
Pharmaceutical companies ramp up efforts to get the brain’s immune cells to help treat Alzheimer’s disease and other conditions, but not everyone agrees the approach will be effective.
Microglia as Therapeutic Targets in Neurodegenerative Diseases
Microglia as Therapeutic Targets in Neurodegenerative Diseases

Pharmaceutical companies ramp up efforts to get the brain’s immune cells to help treat Alzheimer’s disease and other conditions, but not everyone agrees the approach will be effective.

Pharmaceutical companies ramp up efforts to get the brain’s immune cells to help treat Alzheimer’s disease and other conditions, but not everyone agrees the approach will be effective.

microglia
Serious Infections Linked to Autism: Study
Serious Infections Linked to Autism: Study
Abby Olena | Sep 17, 2021
In both a mouse model and the hospital records of more than 3 million children, researchers found a connection between strong immune activation in males and later symptoms of autism spectrum disorder.
Genes for Alcohol Use Disorder and Alzheimer’s Risk Overlap: Study
Genes for Alcohol Use Disorder and Alzheimer’s Risk Overlap: Study
Emma Yasinski | Aug 24, 2021
Genetic, transcriptomic, and epigenetic data reveal molecular mechanisms tying these disorders to each other and to immune disfunction.
Brain’s Lymphatic System Tied to Alzheimer’s Symptoms in Mice
Brain’s Lymphatic System Tied to Alzheimer’s Symptoms in Mice
Amanda Heidt | May 4, 2021
A dysfunctional lymphatic system, described as a clogging of the brain’s sink, may explain why immunotherapies fail in some Alzheimer’s patients.
Study Points to Novel Role for Microglia in Down Syndrome
Study Points to Novel Role for Microglia in Down Syndrome
Catherine Offord | Oct 6, 2020
Overactive immune cells identified in a mouse model and in postmortem human brain tissue may offer a potential therapeutic target for cognitive delays associated with the condition, researchers report.
T Cells and Neurons Talk to Each Other
T Cells and Neurons Talk to Each Other
Ashley Yeager | Oct 1, 2020
Conversations between the immune and central nervous systems are proving to be essential for the healthy social behavior, learning, and memory.
The Brain’s Immune Cells Stand Sentinel Against Viral Invasion
The Brain’s Immune Cells Stand Sentinel Against Viral Invasion
Ashley Yeager | Oct 1, 2020
Some viruses, possibly even SARS-CoV-2, can sneak into the brain through the nose. Recent studies show that microglia are ready for them when they do.
Infographic: How Cytokines Flow into and out of the Brain
Infographic: How Cytokines Flow into and out of the Brain
Ashley Yeager | Oct 1, 2020
Several routes exist for immune cells to communicate with neurons in the central nervous system, though T cells rarely come in direct contact with neural tissue.
How Immune Cells Make the Brain Forget
How Immune Cells Make the Brain Forget
Ashley Yeager | May 1, 2020
Microglia ingest nerve cell connections, leading to the loss of information stored in neuronal circuits.
Image of the Day: Memory Erasure
Image of the Day: Memory Erasure
Amy Schleunes | Feb 12, 2020
By trimming synapses in the adult mouse hippocampus, microglia help facilitate forgetting.
Infographic: The Neurobiology of Suicidal Behavior
Infographic: The Neurobiology of Suicidal Behavior
Catherine Offord | Jan 13, 2020
Clues about the biological mechanisms that contribute to a person’s chance of contemplating or attempting suicide
What Neurobiology Can Tell Us About Suicide
What Neurobiology Can Tell Us About Suicide
Catherine Offord | Jan 13, 2020
The biochemical mechanisms in the brain underlying suicidal behavior are beginning to come to light, and researchers hope they could one day lead to better treatment and prevention strategies.
Can Viruses in the Genome Cause Disease?
Can Viruses in the Genome Cause Disease?
Katarina Zimmer | Jan 1, 2019
Clinical trials that target human endogenous retroviruses to treat multiple sclerosis, ALS, and other ailments are underway, but many questions remain about how these sequences may disrupt our biology.
Microglia Cause Cognitive Decline in Obese Mice
Microglia Cause Cognitive Decline in Obese Mice
Diana Kwon | Sep 10, 2018
The brain’s immune cells gobble up synapses in the hippocampi of rodents fed high-fat or high-sugar diets.
Microglia Remember Bouts of Bodily Inflammation in Mice
Microglia Remember Bouts of Bodily Inflammation in Mice
Ashley Yeager | Apr 11, 2018
A new study reports that immune memory may contribute to neurodegenerative diseases.
Glial Ties to Persistent Pain
Glial Ties to Persistent Pain
Mark R. Hutchinson | Jan 1, 2018
Immune-like cells in the central nervous system are now recognized as key participants in the creation and maintenance of persistent pain.
Infographic: Two Pain Paths Diverge in the Body
Infographic: Two Pain Paths Diverge in the Body
Mark R. Hutchinson | Dec 31, 2017
The acute pain that results from injury or disease is very different from chronic pain.