How to Use P-Values Correctly

The American Statistical Association offers guidance on best practices for the oft-misused tool.

Written byKerry Grens
| 2 min read

Register for free to listen to this article
Listen with Speechify
0:00
2:00
Share

FLICKR, LENDINGMEMOConcerns about widespread misunderstanding and misuse of p-values in science have prompted the American Statistical Association (ASA) to issue its first-ever policy statement about the proper use of the statistical tool. On March 7, the organization released a set of six principles on the power and limitations of the p-value.

For instance, determining policy or making scientific conclusions should not be based on a p-value alone. “Practices that reduce data analysis or scientific inference to mechanical ‘bright-line’ rules (such as ‘p < 0.05’) for justifying scientific claims or conclusions can lead to erroneous beliefs and poor decision-making,” according to the ASA’s statement. “A conclusion does not immediately become ‘true’ on one side of the divide and ‘false’ on the other.”

Rather, complementing p-values with other statistics, such as confidence intervals, may better address the validity of a hypothesis.

In a commentary on the statement, Stanford University’s John Ioannidis wrote that adding more statistical layers does not solve the problems of “hidden multiplicity and selective reporting biases.” Transparency—another of the ASA’s principles—is essential. “Efforts to promote ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!
Already a member? Login Here

Related Topics

Meet the Author

  • kerry grens

    Kerry served as The Scientist’s news director until 2021. Before joining The Scientist in 2013, she was a stringer for Reuters Health, the senior health and science reporter at WHYY in Philadelphia, and the health and science reporter at New Hampshire Public Radio. Kerry got her start in journalism as a AAAS Mass Media fellow at KUNC in Colorado. She has a master’s in biological sciences from Stanford University and a biology degree from Loyola University Chicago.

    View Full Profile
Share
February 2026

A Stubborn Gene, a Failed Experiment, and a New Path

When experiments refuse to cooperate, you try again and again. For Rafael Najmanovich, the setbacks ultimately pushed him in a new direction.

View this Issue
Human-Relevant In Vitro Models Enable Predictive Drug Discovery

Advancing Drug Discovery with Complex Human In Vitro Models

Stemcell Technologies
Redefining Immunology Through Advanced Technologies

Redefining Immunology Through Advanced Technologies

Ensuring Regulatory Compliance in AAV Manufacturing with Analytical Ultracentrifugation

Ensuring Regulatory Compliance in AAV Manufacturing with Analytical Ultracentrifugation

Beckman Coulter Logo
Conceptual multicolored vector image of cancer research, depicting various biomedical approaches to cancer therapy

Maximizing Cancer Research Model Systems

bioxcell

Products

Sino Biological Logo

Sino Biological Pioneers Life Sciences Innovation with High-Quality Bioreagents on Inside Business Today with Bill and Guiliana Rancic

Sino Biological Logo

Sino Biological Expands Research Reagent Portfolio to Support Global Nipah Virus Vaccine and Diagnostic Development

Beckman Coulter

Beckman Coulter Life Sciences Partners with Automata to Accelerate AI-Ready Laboratory Automation

Refeyn logo

Refeyn named in the Sunday Times 100 Tech list of the UK’s fastest-growing technology companies