How to Use P-Values Correctly

The American Statistical Association offers guidance on best practices for the oft-misused tool.

Written byKerry Grens
| 2 min read

Register for free to listen to this article
Listen with Speechify
0:00
2:00
Share

FLICKR, LENDINGMEMOConcerns about widespread misunderstanding and misuse of p-values in science have prompted the American Statistical Association (ASA) to issue its first-ever policy statement about the proper use of the statistical tool. On March 7, the organization released a set of six principles on the power and limitations of the p-value.

For instance, determining policy or making scientific conclusions should not be based on a p-value alone. “Practices that reduce data analysis or scientific inference to mechanical ‘bright-line’ rules (such as ‘p < 0.05’) for justifying scientific claims or conclusions can lead to erroneous beliefs and poor decision-making,” according to the ASA’s statement. “A conclusion does not immediately become ‘true’ on one side of the divide and ‘false’ on the other.”

Rather, complementing p-values with other statistics, such as confidence intervals, may better address the validity of a hypothesis.

In a commentary on the statement, Stanford University’s John Ioannidis wrote that adding more statistical layers does not solve the problems of “hidden multiplicity and selective reporting biases.” Transparency—another of the ASA’s principles—is essential. “Efforts to promote ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!
Already a member? Login Here

Related Topics

Meet the Author

  • kerry grens

    Kerry served as The Scientist’s news director until 2021. Before joining The Scientist in 2013, she was a stringer for Reuters Health, the senior health and science reporter at WHYY in Philadelphia, and the health and science reporter at New Hampshire Public Radio. Kerry got her start in journalism as a AAAS Mass Media fellow at KUNC in Colorado. She has a master’s in biological sciences from Stanford University and a biology degree from Loyola University Chicago.

    View Full Profile
Share
Illustration of a developing fetus surrounded by a clear fluid with a subtle yellow tinge, representing amniotic fluid.
January 2026, Issue 1

What Is the Amniotic Fluid Composed of?

The liquid world of fetal development provides a rich source of nutrition and protection tailored to meet the needs of the growing fetus.

View this Issue
Skip the Wait for Protein Stability Data with Aunty

Skip the Wait for Protein Stability Data with Aunty

Unchained Labs
Graphic of three DNA helices in various colors

An Automated DNA-to-Data Framework for Production-Scale Sequencing

illumina
Exploring Cellular Organization with Spatial Proteomics

Exploring Cellular Organization with Spatial Proteomics

Abstract illustration of spheres with multiple layers, representing endoderm, ectoderm, and mesoderm derived organoids

Organoid Origins and How to Grow Them

Thermo Fisher Logo

Products

Brandtech Logo

BRANDTECH Scientific Introduces the Transferpette® pro Micropipette: A New Twist on Comfort and Control

Biotium Logo

Biotium Launches GlycoLiner™ Cell Surface Glycoprotein Labeling Kits for Rapid and Selective Cell Surface Imaging

Colorful abstract spiral dot pattern on a black background

Thermo Scientific X and S Series General Purpose Centrifuges

Thermo Fisher Logo
Abstract background with red and blue laser lights

VANTAstar Flexible microplate reader with simplified workflows

BMG LABTECH