What’s the Deal with Bacterial Nanotubes?
What’s the Deal with Bacterial Nanotubes?
Several labs have reported the formation of bacterial nanotubes under different, often contrasting conditions. What are these structures and why are they so hard to reproduce?
What’s the Deal with Bacterial Nanotubes?
What’s the Deal with Bacterial Nanotubes?

Several labs have reported the formation of bacterial nanotubes under different, often contrasting conditions. What are these structures and why are they so hard to reproduce?

Several labs have reported the formation of bacterial nanotubes under different, often contrasting conditions. What are these structures and why are they so hard to reproduce?

reproducibility
Infographic: Sources of Variation in Bacterial Nanotube Studies
Infographic: Sources of Variation in Bacterial Nanotube Studies
Sruthi S. Balakrishnan | Jun 1, 2021
Differences in how researchers prepare and image samples can lead to discrepancies in their results.
MDAR Framework Aims to Standardize Reporting in Life Sciences
MDAR Framework Aims to Standardize Reporting in Life Sciences
Shawna Williams | May 7, 2021
Malcolm Macleod, who helped develop these best practices, tells The Scientist how the new guidelines for manuscript publishing seek to support a push for transparent and thorough sharing of methods and data.
Opinion: The Rise of Preprints Is No Cause for Alarm
Opinion: The Rise of Preprints Is No Cause for Alarm
Jonny Coates | Apr 14, 2021
At a time of fast-paced science and rampant misinformation, can we trust the non–peer-reviewed literature?
STRANGE Framework Addresses Bias in Animal Behavior Research
STRANGE Framework Addresses Bias in Animal Behavior Research
Amanda Heidt | Jan 27, 2021
The journal Ethology is the first to adopt the guidelines, aimed at clarifying experimental design and the potential biases within.
Research Teams Reach Different Results From Same Brain-Scan Data
Research Teams Reach Different Results From Same Brain-Scan Data
Ruth Williams | May 20, 2020
When 70 independent teams were tasked with analyzing identical brain images, no two teams chose the same approach and their conclusions were highly variable.
UK Group Tackles Reproducibility in Research
UK Group Tackles Reproducibility in Research
Emily Makowski | Jan 7, 2020
Last month, 10 UK universities became part of the UK Reproducibility Network, joining researchers, funders, journal publishers, and regulatory agencies.
Opinion: Scientists Need to Demand Better Antibody Validation
Opinion: Scientists Need to Demand Better Antibody Validation
Peter S. McPherson | Oct 15, 2019
My lab has developed a protocol to easily assess the specificity of antibodies—and hopefully stem some of the reproducibility crisis.
Replication Refutes Study Linking Neuroimaging to Genetics
Replication Refutes Study Linking Neuroimaging to Genetics
Emma Yasinski | Sep 30, 2019
The original experiment found brain activity as measured by fMRI was tied to particular genetic variants.
Two Studies Fail to Replicate Magnetogenetics Research
Two Studies Fail to Replicate Magnetogenetics Research
Katarina Zimmer | Sep 20, 2019
The new work calls into question the idea that neurons can be genetically engineered to fire in response to magnetic fields, a setback for the budding technique.
New Journal Seeks Typically Overlooked Studies
New Journal Seeks Typically Overlooked Studies
Emily Makowski | Sep 18, 2019
Its articles will include negative results, reproducibility studies, and peer reviewers’ names.
Fixing the Flaws in Animal Research
Fixing the Flaws in Animal Research
Diana Kwon | Sep 1, 2019
Many preclinical studies carried out in vivo are poorly designed and generate irreproducible data, but efforts to address the problem are on the rise.
Potential Causes of Irreproducibility Revealed
Potential Causes of Irreproducibility Revealed
Abby Olena | Jul 11, 2019
Five independent groups got different results in a drug-response experiment, despite sharing protocols, reagents, and cell lines. The researchers identify technical variables that could be to blame.
Ten Minute Sabbatical
Ten Minute Sabbatical
The Scientist Staff | Jun 1, 2019
Take a break from the bench to puzzle and peruse.
Microbes May Take Some of the Blame for the Reproducibility Crisis
Microbes May Take Some of the Blame for the Reproducibility Crisis
Emma Yasinski | Apr 5, 2019
Scientists find varied microbiota among the same strain of mice from four vendors—and that variability affects their susceptibility to infection.
HeLa Cells from Different Labs Vary in Genetics, Phenotype
HeLa Cells from Different Labs Vary in Genetics, Phenotype
Katarina Zimmer | Feb 26, 2019
This could account for some reproducibility problems in cell line research, according to the authors of a comprehensive analysis of HeLa variants.
The Open Data Explosion
The Open Data Explosion
Viviane Callier | Jan 1, 2019
Scientists are working to maximize the benefits and minimize the costs of sharing.
Q&A: John Ioannidis Talks Transparency in Biomedical Literature
Q&A: John Ioannidis Talks Transparency in Biomedical Literature
Shawna Williams | Nov 20, 2018
The Stanford University researcher discusses a new study on measures such as data sharing and funding disclosures.
Half the Time, Psychology Results Not Reproducible: Study
Half the Time, Psychology Results Not Reproducible: Study
Ashley P. Taylor | Nov 20, 2018
These failures were not due to differences among sample populations.