Glass dishes of blue liquid
Study Finds Reproducibility Issues in High-Impact Cancer Papers
Researchers involved in an eight-year project to reproduce the findings of more than 50 high-impact papers struggled to get enough information to even carry out most of the experiments.
ABOVE: © ISTOCK.COM, PHOTOEVENT
Study Finds Reproducibility Issues in High-Impact Cancer Papers
Study Finds Reproducibility Issues in High-Impact Cancer Papers

Researchers involved in an eight-year project to reproduce the findings of more than 50 high-impact papers struggled to get enough information to even carry out most of the experiments.

Researchers involved in an eight-year project to reproduce the findings of more than 50 high-impact papers struggled to get enough information to even carry out most of the experiments.

ABOVE: © ISTOCK.COM, PHOTOEVENT

reproducibility

A scanning electron micrograph of a coculture of E. coli and Acinetobacter baylyi. Nanotubes can be seen extending from the E. coli.
What’s the Deal with Bacterial Nanotubes?
Sruthi S. Balakrishnan | Jun 1, 2021
Several labs have reported the formation of bacterial nanotubes under different, often contrasting conditions. What are these structures and why are they so hard to reproduce?
An illustration of a flask of bacteria, a weighted microscope slide, and two bacteria exchanging materials via nanotubes.
Infographic: Sources of Variation in Bacterial Nanotube Studies
Sruthi S. Balakrishnan | Jun 1, 2021
Differences in how researchers prepare and image samples can lead to discrepancies in their results.
The Gripper Tower lab scene epMotion
Automating NGS Library Prep
The Scientist Creative Services Team, Eppendorf | Apr 12, 2022
Liquid handlers specialized for next-generation sequencing (NGS) automate nucleic acid extraction and library preparation from microbiome samples.
a blue pen checks off boxes in a list
MDAR Framework Aims to Standardize Reporting in Life Sciences
Shawna Williams | May 7, 2021
Malcolm Macleod, who helped develop these best practices, tells The Scientist how the new guidelines for manuscript publishing seek to support a push for transparent and thorough sharing of methods and data.
preprint academic publishing science research covid-19 coronavirus pandemic reproducibility
Opinion: The Rise of Preprints Is No Cause for Alarm
Jonny Coates | Apr 14, 2021
At a time of fast-paced science and rampant misinformation, can we trust the non–peer-reviewed literature?
SciNote
No More Messy Notes: Modernizing the Lab Notebook
The Scientist Creative Services Team, SciNote | Mar 25, 2022
An electronic laboratory notebook (ELN) keeps data organized and secure, boosting productivity and reproducibility.
animal behavior, animal cognition, reproducibility, replication, publishing, research integrity, animal research, experimental design, data reporting
STRANGE Framework Addresses Bias in Animal Behavior Research
Amanda Heidt | Jan 27, 2021
The journal Ethology is the first to adopt the guidelines, aimed at clarifying experimental design and the potential biases within.
a cartoon of a human head with arrows going in different directions and speech bubble that say "yes!" and "no!"
Research Teams Reach Different Results From Same Brain-Scan Data
Ruth Williams | May 20, 2020
When 70 independent teams were tasked with analyzing identical brain images, no two teams chose the same approach and their conclusions were highly variable.
Traceable, Reliable, and Reproducible Science: TRACKMAN® Connected
The Scientist Creative Services Team | Oct 22, 2020
TRACKMAN® Connected is a tablet with accessories and apps that makes pipetting faster and more verifiable, which improves reliability, traceability, and reproducibility at the bench.  
UK Group Tackles Reproducibility in Research
Emily Makowski | Jan 7, 2020
Last month, 10 UK universities became part of the UK Reproducibility Network, joining researchers, funders, journal publishers, and regulatory agencies.
antibody validation reproducibility crisis C9ORF72
Opinion: Scientists Need to Demand Better Antibody Validation
Peter S. McPherson | Oct 15, 2019
My lab has developed a protocol to easily assess the specificity of antibodies—and hopefully stem some of the reproducibility crisis.
mri fmri neuroscience genetics cognition
Replication Refutes Study Linking Neuroimaging to Genetics
Emma Yasinski | Sep 30, 2019
The original experiment found brain activity as measured by fMRI was tied to particular genetic variants.
magnetogenetics neuroscience techniques
Two Studies Fail to Replicate Magnetogenetics Research
Katarina Zimmer | Sep 20, 2019
The new work calls into question the idea that neurons can be genetically engineered to fire in response to magnetic fields, a setback for the budding technique.
New Journal Seeks Typically Overlooked Studies
Emily Makowski | Sep 18, 2019
Its articles will include negative results, reproducibility studies, and peer reviewers’ names.
Fixing the Flaws in Animal Research
Diana Kwon | Sep 1, 2019
Many preclinical studies carried out in vivo are poorly designed and generate irreproducible data, but efforts to address the problem are on the rise.
Potential Causes of Irreproducibility Revealed
Abby Olena | Jul 11, 2019
Five independent groups got different results in a drug-response experiment, despite sharing protocols, reagents, and cell lines. The researchers identify technical variables that could be to blame.
bacteria crossword
Ten Minute Sabbatical
The Scientist Staff | Jun 1, 2019
Take a break from the bench to puzzle and peruse.
black lab mice microbiome
Microbes May Take Some of the Blame for the Reproducibility Crisis
Emma Yasinski | Apr 5, 2019
Scientists find varied microbiota among the same strain of mice from four vendors—and that variability affects their susceptibility to infection.
HeLa Cells from Different Labs Vary in Genetics, Phenotype
Katarina Zimmer | Feb 26, 2019
This could account for some reproducibility problems in cell line research, according to the authors of a comprehensive analysis of HeLa variants.