Let’s Talk About Sex

In lieu of a career in punk rock, James Pfaus opted to study the brain signals underlying sexual behavior and then see what happened when he manipulated them.

Written byMegan Scudellari
| 9 min read

Register for free to listen to this article
Listen with Speechify
0:00
9:00
Share

JAMES G. PFAUS
Professor, Center for Studies
in Behavioral Neurobiology
Concordia University
Montréal, Québec
© DAVID GIRAL
As an undergraduate at American University in Washington, DC, Jim Pfaus played guitar in two local punk bands while also studying psychology and working in labs at the university, Planned Parenthood, and the National Institutes of Health (NIH). “I honestly wasn’t sure what I wanted to do with my life,” he says. Ultimately, Pfaus opted to go to graduate school to study sexual behavior and keep music as a hobby. “I figured there’s no way the government would give me grants to do sex research in my basement, so that helped me make up my mind,” says Pfaus with a laugh.

It was the beginning of a whirlwind romance with behavioral neurobiology. In studies on rats and humans, Pfaus has mapped out neurotransmitter systems, cell-signaling mechanisms, and behavioral responses to sexual stimuli. He has also shown that a species’ sexual behaviors are not fixed; they can be conditioned and changed.

“Everybody seems to do it, so what is it about sex that is so taboo?”

Here, Pfaus opens his little black book to divulge how the word “sex” got him suspended from primary school, why good sex is like a good drug, and how targeting excitatory brain systems could help treat sexual dysfunction.

Three-letter word. “When I was in elementary school, I had a precocious interest in sex. As far [back] as I can remember, I ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to digital editions of The Scientist, as well as TS Digest, feature stories, more than 35 years of archives, and much more!
Already a member? Login Here

Related Topics

Meet the Author

Published In

Share
Image of a woman with her hands across her stomach. She has a look of discomfort on her face. There is a blown up image of her stomach next to her and it has colorful butterflies and gut bacteria all swarming within the gut.
November 2025, Issue 1

Why Do We Feel Butterflies in the Stomach?

These fluttering sensations are the brain’s reaction to certain emotions, which can be amplified or soothed by the gut’s own “bugs".

View this Issue
Olga Anczukow and Ryan Englander discuss how transcriptome splicing affects immune system function in lung cancer.

Long-Read RNA Sequencing Reveals a Regulatory Role for Splicing in Immunotherapy Responses

Pacific Biosciences logo
Research Roundtable: The Evolving World of Spatial Biology

Research Roundtable: The Evolving World of Spatial Biology

Conceptual cartoon image of gene editing technology

Exploring the State of the Art in Gene Editing Techniques

Bio-Rad
Conceptual image of a doctor holding a brain puzzle, representing Alzheimer's disease diagnosis.

Simplifying Early Alzheimer’s Disease Diagnosis with Blood Testing

fujirebio logo

Products

Labvantage Logo

LabVantage Solutions Awarded $22.3 Million U.S Customs and Border Protection Contract to Deliver Next-Generation Forensic LIMS

The Scientist Placeholder Image

Evosep Unveils Open Innovation Initiative to Expand Standardization in Proteomics

OGT logo

OGT expands MRD detection capabilities with new SureSeq Myeloid MRD Plus NGS Panel