Linoleic Acid Derivatives Potentially Mediate Pain and Itch in the Skin

Researchers uncover a family of compounds that may be involved in pain transmission.

Written byKatarina Zimmer
| 2 min read

Register for free to listen to this article
Listen with Speechify
0:00
2:00
Share

OMEGA-6 FIELDS: Linoleic acid is plentiful in soy and other common components of modern Western diets.© ISTOCK.COM/SCALATORE1959

The paper C.E. Ramsden et al., “A systems approach for discovering linoleic acid derivatives that potentially mediate pain and itch,” Sci Signal, doi:10.1126/scisignal.aal5241, 2017. Pluses and Minuses Linoleic acid, also known as omega-6 fatty acid—abundant in many vegetable and seed oils—is essential for forming our skin’s waxy, waterproof barrier, and has become an increasingly common component of modern Western diets. Research has linked it to pain and chronic headaches, and Christopher Ramsden, a nutrition researcher at the National Institute on Aging, wanted to know why. Scratching the Itch Ramsden and colleagues explored eight linoleic acid derivatives in human and rat skin. They prospected for the compounds in inflamed psoriatic skin lesions in humans, and injected them into mice to see if they would induce itching. ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to digital editions of The Scientist, as well as TS Digest, feature stories, more than 35 years of archives, and much more!
Already a member? Login Here

Related Topics

Meet the Author

  • katya katarina zimmer

    After a year teaching an algorithm to differentiate between the echolocation calls of different bat species, Katarina decided she was simply too greedy to focus on one field of science and wanted to write about all of them. Following an internship with The Scientist in 2017, she’s been happily freelancing for a number of publications, covering everything from climate change to oncology. Katarina is a news correspondent for The Scientist and contributes occasional features to the magazine. Find her on Twitter @katarinazimmer and read her work on her website.

    View Full Profile

Published In

January 2018

The Science of Pain

New research on an age-old ailment

Share
December digest cover image of a wooden sculpture comprised of multiple wooden neurons that form a seahorse.
December 2025, Issue 1

Wooden Neurons: An Artistic Vision of the Brain

A neurobiologist, who loves the morphology of cells, turns these shapes into works of art made from wood.

View this Issue
Alzheimer: Phosphorylation of Tau proteins leads to disintegration of microtubuli in a neuron axon stock photo

Advancing Alzheimer’s Disease Detection with Brain-Derived pTau217 Assays

Alamar Biosciences logo
Abstract pattern of multicolored circles on a dark background, representing immune cell diversity and single-cell sequencing resolution.

Exploring Immune Diversity at the Single-Cell Level

parse-biosciences-logo
Stacks of cell culture dishes, plates, and flasks with pink cell culture medium on a white background.

Driving Innovation with Cell Culture Essentials

Merck
Stacks of cell culture dishes, plates, and flasks with pink cell culture medium on a white background.

Driving Innovation with Cell Culture Essentials

MilliporeSigma purple logo

Products

Beckman Logo

Beckman Coulter Life Sciences Introduces the Biomek i3 Benchtop Liquid Handler, a Small but Mighty Addition to its Portfolio of Automated Workstations

brandtech logo

BRANDTECH® Scientific Announces Strategic Partnership with Copia Scientific to Strengthen Sales and Service of the BRAND® Liquid Handling Station (LHS) 

Top Innovations 2026 Contest Image

Enter Our 2026 Top Innovations Contest

Biotium Logo

Biotium Expands Tyramide Signal Amplification Portfolio with Brighter and More Stable Dyes for Enhanced Spatial Imaging