Linoleic Acid Derivatives Potentially Mediate Pain and Itch in the Skin

Researchers uncover a family of compounds that may be involved in pain transmission.

katya katarina zimmer
| 2 min read

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OMEGA-6 FIELDS: Linoleic acid is plentiful in soy and other common components of modern Western diets.© ISTOCK.COM/SCALATORE1959

The paper C.E. Ramsden et al., “A systems approach for discovering linoleic acid derivatives that potentially mediate pain and itch,” Sci Signal, doi:10.1126/scisignal.aal5241, 2017. Pluses and Minuses Linoleic acid, also known as omega-6 fatty acid—abundant in many vegetable and seed oils—is essential for forming our skin’s waxy, waterproof barrier, and has become an increasingly common component of modern Western diets. Research has linked it to pain and chronic headaches, and Christopher Ramsden, a nutrition researcher at the National Institute on Aging, wanted to know why. Scratching the Itch Ramsden and colleagues explored eight linoleic acid derivatives in human and rat skin. They prospected for the compounds in inflamed psoriatic skin lesions in humans, and injected them into mice to see if they would induce itching. ...

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Meet the Author

  • katya katarina zimmer

    Katarina Zimmer

    After a year teaching an algorithm to differentiate between the echolocation calls of different bat species, Katarina decided she was simply too greedy to focus on one field. Following an internship with The Scientist in 2017, she has been happily freelancing for a number of publications, covering everything from climate change to oncology.

Published In

January 2018

The Science of Pain

New research on an age-old ailment

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