January 2018

The Science of Pain

New research on an age-old ailment

Features

Targeting Sodium Channels for Pain Relief

Glial Ties to Persistent Pain

Animal Analgesics

geography cone shell, Conus geographus, hunting at night, Lady Elliot Island, Great Barrier Reef Marine Park, South Pacific Ocean, Queensland, Australia

Novel Analgesics at a Snail’s Pace

Researchers Mine Centipede Toxins for Analgesics

Mining Spider Toxins for Analgesic Clues

Toxin from a Dangerous Fish Delicacy

Sourcing Painkillers from Scorpions’ Stings

Sea Anemone Toxin Could Treat Autoimmunity

Frog Skin Yields Potent Painkillers, but None Clinic Ready

The Black Mamba is the longest, fastest and most dangerous venomous snake of Africa.

Snake Venoms Cause and Block Pain

Contributors

Contributors

Editorial

Prizes and Penalties

Speaking of Science

Ten-Minute Sabbatical

Freeze Frame

Caught on Camera

Notebook

What Bat Quarrels Tell Us About Vocal Learning

Sex Differences in Opioid Analgesia: A Complicated Picture

Researchers Team Up with Patients to Build a Breast Cancer Database

Mothers Are Hard-Wired to Respond Similarly to Infant Cries Across Cultures

Online First

Child Receives Transgenic Skin

Modus Operandi

3-D–Printed Ethoscopes Lower Barriers to Large-Scale Fly Behavior Studies

The Literature

Distinct Regions Drive Responses to Anxiety, Fear

Skin “Remembers” Wounds, Heals Faster the Second Time Around

Linoleic Acid Derivatives Potentially Mediate Pain and Itch in the Skin

Profiles

David Julius Probes the Molecular Mechanics of Pain

Scientist to Watch

Annina Schmid Dissects Nerve Disorders

Lab Tools

High-Throughput Epigenetics Analyses

Bio Business

The Quest for Safer Opioid Drugs

Reading Frames

Why Swearing and Pain Go Hand in Hand

Book Excerpt from Swearing is Good for You

Foundations

Atlas of Mars by Giovanni Schiaparelli, made in 1888. Note that this is a South-Up map; the South Pole is on top.

Fake News: Mars Edition, circa 1877

Image of small blue creatures called Nergals. Some have hearts above their heads, which signify friendship. There is one Nergal who is sneezing and losing health, which is denoted by minus one signs floating around it.
June 2025, Issue 1

Nergal Networks: Where Friendship Meets Infection

A citizen science game explores how social choices and networks can influence how an illness moves through a population.

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Unraveling Complex Biology with Advanced Multiomics Technology

Unraveling Complex Biology with Five-Dimensional Multiomics

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Resurrecting Plant Defense Mechanisms to Avoid Crop Pathogens

Resurrecting Plant Defense Mechanisms to Avoid Crop Pathogens

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Seeing and Sorting with Confidence

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Streamlining Microbial Quality Control Testing

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Products

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Agilent Unveils the Next Generation in LC-Mass Detection: The InfinityLab Pro iQ Series

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Pioneering Cancer Plasticity Atlas will help Predict Response to Cancer Therapies

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How Alderley Analytical are Delivering eXtreme Robustness in Bioanalysis