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January 2018

The Science of Pain

New research on an age-old ailment

Features

Targeting Sodium Channels for Pain Relief

Glial Ties to Persistent Pain

Animal Analgesics

geography cone shell, Conus geographus, hunting at night, Lady Elliot Island, Great Barrier Reef Marine Park, South Pacific Ocean, Queensland, Australia

Novel Analgesics at a Snail’s Pace

Researchers Mine Centipede Toxins for Analgesics

Mining Spider Toxins for Analgesic Clues

Toxin from a Dangerous Fish Delicacy

Sourcing Painkillers from Scorpions’ Stings

Sea Anemone Toxin Could Treat Autoimmunity

Frog Skin Yields Potent Painkillers, but None Clinic Ready

The Black Mamba is the longest, fastest and most dangerous venomous snake of Africa.

Snake Venoms Cause and Block Pain

Reading Frames

Book Excerpt from Swearing is Good for You

Why Swearing and Pain Go Hand in Hand

Contributors

Contributors

Editorial

Prizes and Penalties

Speaking of Science

Ten-Minute Sabbatical

Freeze Frame

Caught on Camera

Notebook

What Bat Quarrels Tell Us About Vocal Learning

Sex Differences in Opioid Analgesia: A Complicated Picture

Researchers Team Up with Patients to Build a Breast Cancer Database

Mothers Are Hard-Wired to Respond Similarly to Infant Cries Across Cultures

Online First

Child Receives Transgenic Skin

Modus Operandi

3-D–Printed Ethoscopes Lower Barriers to Large-Scale Fly Behavior Studies

The Literature

Distinct Regions Drive Responses to Anxiety, Fear

Skin “Remembers” Wounds, Heals Faster the Second Time Around

Linoleic Acid Derivatives Potentially Mediate Pain and Itch in the Skin

Profiles

David Julius Probes the Molecular Mechanics of Pain

Scientist to Watch

Annina Schmid Dissects Nerve Disorders

Lab Tools

High-Throughput Epigenetics Analyses

Bio Business

The Quest for Safer Opioid Drugs

Foundations

Atlas of Mars by Giovanni Schiaparelli, made in 1888. Note that this is a South-Up map; the South Pole is on top.

Fake News: Mars Edition, circa 1877

August 2026 Digest cover
August 2026

Epic Fail: Sea-Monkeys Sabotage Fieldwork

When Barry Hicks set out to photograph thrombolites, thousands of unexpected visitors photobombed his underwater images.

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Advancing Respiratory Immunity Through Tissue-Resident Memory T Cell Research

Advancing Respiratory Immunity Through Tissue-Resident Memory T Cell Research

Miltenyi
Overcoming Immunotherapy Resistance in Liver Cancer

Overcoming Immunotherapy Resistance in Liver Cancer

Axion Biosystems
Optimizing NGS Library Preparation for Reliable Sequencing Data

Optimizing NGS Library Preparation for Reliable Sequencing Data

Covaris
Using TCR Repertoire Sequencing to Advance Immunology Research

Using TCR Repertoire Sequencing to Advance Immunology Research

Miltenyi

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Sino Biological Launches Precisely Characterized Full-Length p-Tau217 Protein to Advance Next-Generation Alzheimer’s Biomarker Assay Development

A photo of a scientist placing the Resipher device on a 96-well plate.

Resipher: Continuous Live-Cell Mitochondrial Respiration Monitoring in 96-Well Plates

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