Features

Are the Kids Alright?

Vitamin D on Trial

Child-Proofing Drugs
Slideshows

A Whiff of TB
Chemical ecologist Max Suckling at the Institute for Plant and Food Research Ltd., and summer student Rachael Sagar use Pavlovian conditioning to train bees to stick out their tongues, or proboscises, at the scent of odors produced by tuberculosis-causing bacteria.

Electron Microscopy Through the Ages
Take a tour through the revolutionary menthod's past, present, and future.
Contributors

Contributors
Meet some of the people featured in the March 2012 issue of The Scientist.
Capsule Reviews

Capsule Reviews
The Wandering Gene and the Indian Princess, The Forever Fix, Connectome, and DNA USA
Infographics

How Drugs Interact with a Baby’s Parts
A lot changes in a child’s body over the course of development, and not all changes occur linearly: gene expression can fluctuate, and organs can perform different functions on the way to their final purpose in the body. Here are some of the key deve

Suspected Effects of Vitamin D
Vitamin D has a variety of actions in the body. It binds to the vitamin D receptor (VDR), which then binds to the retinoid X receptor (RXR) and activates the expression of numerous genes.

How the Pediatric Laws Work
The Pediatric Research Equity Act (PREA) of 2003 requires that companies developing new drugs that could be used to treat a condition in children perform clinical trials in kids before winning FDA approval.
Bio Business

Braving the IPO Drought
Despite nervous investors and a volatile market, a courageous few biotechnology companies are taking their chances on Wall Street.
Scientist to Watch

David Sabatini: Demystifying mTOR
Principal Investigator, Whitehead Institute for Biomedical Research. Associate Professor, Department of Biology, Massachusetts Institute of Technology. Age: 44
Speaking of Science

Speaking of Science
March 2012's selection of notable quotes
Modus Operandi

Delivering Silence
Using RNA viruses to silence genes could optimize tissue targeting while reducing toxicity.
The Literature

How to Make Eyeball Stew
Editor's choice in developmental biology

Biota Babble
Editor's choice in immunology

Promoting Death
Editor's choice in biochemistry
Notebook

T-Bee
Two researchers are trying to train bees to sniff out tuberculosis.

The Joint Collector
Forget stamps: one bioengineer amasses broken artificial joints to learn why they failed and how to build better ones.

Snake Tales
An anthropologist and a herpetologist join forces to reveal the complex shared evolutionary and ecological history of pythons and primates.

Test-Tube Zoo Babies
A National Zoo researcher works to perfect gamete preservation and in vitro fertilization techniques in order to better manage endangered populations.
Editorial

Tricky Trials
Studies on safety, efficacy, or dosing of drugs in children, or on nutritional supplements, are not run-of-the-mill.
Critic at Large

One Year On
Some thoughts about the ecological fallout from Fukushima
Videos

Preserving Endangered Gametes
Pierre Comizzoli, a reproductive physiologist at the Smithsonian Conservation Biology Institute, chats about his efforts to rescue endangered species from extinction using in vitro fertilization as well as novel gamete preservation techniques.
Foundations

The Subcellular World Revealed, 1945
The first electron microscope to peer into an intact cell ushers in the new field of cell biology.
Lab Tools

Combing the Cancer Genome
A guided tour through the main online resources for analyzing cancer genomics data
Profiles

Model Citizen
With an eye to understanding animal regeneration, Alejandro Sánchez Alvarado has turned a freshwater planarian into a model system to watch.
Thought Experiment

Who Are We Really?
Manipulating the human microbiome has ethical implications.
Reading Frames

The Specter of Denialism
Conspiracy theories surrounding the global HIV/AIDS epidemic have cost thousands of lives. But science is fighting back.