Papers to Watch
Papers to Watch
N. Stern-Ginossar, et al., "Host immune system gene targeting by a viral miRNA." Science, 317:376-81, July 20, 2007. Upon infection of its host, human cytomegalovirus (HCMV) expresses a miRNA that directly down-regulates expression of an immunorelated gene, MICB. Thus, it appears that HCMV has developed two distinct mechanisms to down-regulate expression of the same immunorelated gene, with the RNA-based strategy presumably being more ancient. -