Memories Can Distort the Brain’s GPS

Two independent studies in rats find grid cells, which form the brain’s map, are more plastic than thought and are subject to the influence of reward.

emma yasinski
| 4 min read

Register for free to listen to this article
Listen with Speechify
0:00
4:00
Share

ABOVE: © ISTOCK.COM, BESTBRK

In the 1970s, scientists discovered that certain neurons in the hippocampus—an area of the brain involved in learned and memory—would fire in response to particular locations. They were called “place cells,” explains Charlotte Boccara, a researcher at the University of Oslo. “They were deemed important for spatial representation . . . a bit like the ‘You Are Here’ signal’ on a map.”

But it wasn’t until 2005 that researchers discovered the brain’s grid cells, which they believed function as that map. These cells, found adjacent to the hippocampus in the medial entorhinal cortex (MEC), self-organize into a pattern of hexagons that serve as coordinates to help animals make sense of their surroundings and the signals from our place cells.

A pair of studies published today (March 28) in Science suggests that this map may not be as rigid as once thought. The experiments demonstrated that, in ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!
Already a member? Login Here

Keywords

Meet the Author

  • emma yasinski

    Emma Yasinski

    Emma is a Florida-based freelance journalist and regular contributor for The Scientist.
Share
3D illustration of a gold lipid nanoparticle with pink nucleic acid inside of it. Purple and teal spikes stick out from the lipid bilayer representing polyethylene glycol.
February 2025, Issue 1

A Nanoparticle Delivery System for Gene Therapy

A reimagined lipid vehicle for nucleic acids could overcome the limitations of current vectors.

View this Issue
Enhancing Therapeutic Antibody Discovery with Cross-Platform Workflows

Enhancing Therapeutic Antibody Discovery with Cross-Platform Workflows

sartorius logo
Considerations for Cell-Based Assays in Immuno-Oncology Research

Considerations for Cell-Based Assays in Immuno-Oncology Research

Lonza
An illustration of animal and tree silhouettes.

From Water Bears to Grizzly Bears: Unusual Animal Models

Taconic Biosciences
Sex Differences in Neurological Research

Sex Differences in Neurological Research

bit.bio logo

Products

Photo of a researcher overseeing large scale production processes in a laboratory.

Scaling Lentiviral Vector Manufacturing for Optimal Productivity

Thermo Fisher Logo
Collage-style urban graphic of wastewater surveillance and treatment

Putting Pathogens to the Test with Wastewater Surveillance

An illustration of an mRNA molecule in front of a multicolored background.

Generating High-Quality mRNA for In Vivo Delivery with lipid nanoparticles

Thermo Fisher Logo
Tecan Logo

Tecan introduces Veya: bringing digital, scalable automation to labs worldwide