FLICKR, NICK SALTMARSHA team of researchers has taken a step toward modifying pigs to become viable alternatives to human organ donors, George Church from Harvard University announced at a US National Academy of Sciences meeting earlier this week (October 5), according to Nature.
Doctors have been slow to use pigs as organ-donor alternatives for at least two reasons: first, the pig genome has a number of endogenous retroviruses that are harmless to pigs, but that could infect humans; second, the human immune system will target pig-specific proteins in the cell membranes, trying to reject the foreign bodies.
Church and his colleagues used CRISPR/Cas9 to inactivate 62 of the pig’s endogenous retroviruses in embryos. In a separate set of pig embryos, the team modified genes coding for the cell membrane proteins that would trigger a human immune response. Pigs intended as organ donors in the future will require both sets of gene edits, which amount to ten times more than previous edits in other animals.
CRISPR pioneer Jennifer Doudna, ...
