A karyotype of chromosomes mostly stained blue with one stained red and green
Researchers Fuse Mouse Chromosomes in Scientific First
The findings will likely help elucidate the effects of chromosome fusions, which can cause disease but have also contributed to evolution.
Researchers Fuse Mouse Chromosomes in Scientific First
Researchers Fuse Mouse Chromosomes in Scientific First

The findings will likely help elucidate the effects of chromosome fusions, which can cause disease but have also contributed to evolution.

The findings will likely help elucidate the effects of chromosome fusions, which can cause disease but have also contributed to evolution.

gene editing
A gloved hand holds a tweezer and pulls a section of DNA away from a double helix
First Person Dosed in Novel Gene Editing Clinical Trial
Amanda Heidt | Jul 12, 2022
The biotech company Verve Therapeutics launched the study with the aim of using base editing to treat a genetic condition that causes high cholesterol and increases a person's risk of developing cardiovascular disease.
Green-tinged image of fly eye with shiny and black portions
New CRISPR Technique Causes Few Unintended Mutations in Fruit Flies
Jason P. Dinh | Jul 1, 2022
A study finds that CRISPR-Nickase, which changes just one allele of a given gene, improves gene editing efficiency compared with CRISPR-Cas9.
Learn How Cutting-Edge Science is Breaking Through Industry Barriers
Focus on Innovation: Scientific Advances Driving Biopharma Market Trends
The Scientist Creative Services Team and Tecan
Explore the future of biopharma research and development.
an artistic rendering of CRISPR/Cas9
Ten Years of CRISPR
Sophie Fessl | Jun 28, 2022
This month marks ten years since CRISPR-Cas9 was repurposed as a gene editing system, so we’re looking back at what has been accomplished in a decade of CRISPR editing.
Two prime editing guide RNAs (pegRNAs), deliver Cas9 enzymes to targeted regions of the genome.
Infographic: Two Guide RNAs Make for Large, Stable Insertions
Dan Robitzski | Jun 13, 2022
A new technique goes beyond CRISPR and writes two complementary strands of DNA directly into the genome.
The Past, Present, and Future of Cell and Gene Therapy
The Past, Present, and Future of Cell and Gene Therapy
The Scientist Creative Services Team and Bio-Rad Laboratories
Embark on the journey of cell and gene therapy—from its conception and development, to its present state, and into its future.
Genetic Syndrome and Genetic Disorder, 3D illustration of science concept.
With Two RNA Guides, Editing Technique Writes Long DNA Insertions
Dan Robitzski | Jun 13, 2022
The approach, called GRAND, uses a second guide RNA to write complementary strands of DNA in targeted genomic locations, resulting in efficient insertions that can be hundreds of base pairs long.
A cockroach clings to the inside of a white mug.
Injecting Cockroaches with CRISPR Gene Edits Their Offspring
Sophie Fessl | May 25, 2022
A new method has allowed researchers to conduct the first gene knock-out and knock-in edits on cockroaches and may extend to many other insects.
Challenges and Applications
Combinatorial Single Cell CRISPR Screens: Challenges and Applications
The Scientist Creative Services Team in collaboration with 10x Genomics
An expert panel will discuss how single cell sequencing enhances throughput in CRISPR gene editing applications.
Alcohol bottles at a bar
Epigenome Editing Decreases Alcohol Seeking and Anxiety in Rats
Natalia Mesa | May 20, 2022
A CRISPR-based system that reverses epigenetic changes caused by adolescent binge drinking reduces adult addiction-like behaviors in rats, a study finds, suggesting that an epigenomic approach could someday help treat people with alcohol use disorder.
close-up of an Aedes aegypti mosquito on human skin
Researchers Discover What Attracts Mosquitoes to Humans
Sophie Fessl | May 11, 2022
A brain area of Aedes aegypti responds specifically to components of human sebum, a study finds.
CRISPR for Genome Engineering in Drosophila
Technique Talk: CRISPR for Genome Engineering in Drosophila
The Scientist Creative Services Team
Discover how CRISPR is revolutionizing gene editing in a classic genetics research model.
An orange CRISPR Cas 9 enzyme cutting DNA
CRISPR-Based Treatment Successfully Lowers Toxic Protein Levels
Natalia Mesa | Mar 2, 2022
A first-of-its-kind gene therapy dramatically reduced misfolded protein levels in some clinical trial participants for up to six months and reduced levels in all participants for up to a year.
Vector illustration of a courthouse with test tubes as pillars
CRISPR Patent Ruling Favors Broad Institute
Jef Akst | Mar 1, 2022
The US Patent and Trademark Office has once again decided that the institute has priority over the University of California and collaborators regarding intellectual property rights for CRISPR-Cas9 gene editing in eukaryotes. But the fight over the technique isn’t over.
untitled-design
From Bench to Boardroom
Aparna Nathan
Taking inspiration from her PhD research, Ana Moreno formed a company where scientists use CRISPR to treat chronic pain
DNA
In Editing RNA, Researchers See Endless Possibilities
Christie Wilcox | Dec 1, 2021
RNA editing has been in DNA editing’s shadow for nearly a decade, but recent investments in the technology could bring it into the limelight.
Infographic showing endogenous adenosine enzymes acting on RNA (ADARs) edit genetic material in the cell by attaching to naturally occurring double-stranded RNAs, including mRNAs, and switching out A bases with I bases (left). Therapeutic RNA editing platforms based on this mechanism fall into one of two categories: either they use engineered enzymes, which generally consist of the editing part of the ADAR enzyme attached to another protein such as Cas13 that boosts specificity, alongside a guide RNA that targets the enzyme to the desired location (middle); or they consist of a guide RNA alone, which recruits an endogenous ADAR to edit the target sequence (right).
Infographic: RNA Editing Approaches
Christie Wilcox | Dec 1, 2021
RNA editing platforms leverage the natural activity of ADAR enzymes to make key changes to messenger RNAs before they are translated into proteins.
800-x-560-sept-tss
The Scientist Speaks - Homing in on New Anticancer Targets 
Sejal Davla, PhD
Jason Sheltzer discusses cancer mechanisms leading to drug resistance and new approaches to find drug targets.
Lizard on glass tank
Engineered Stem Cells Grant Geckos “Perfectly” Regenerated Tails
Chloe Tenn | Nov 5, 2021
Geckos injected with neural stem cells modified to block cartilage growth developed the skeletal and nervous components normally lacking from regrown tails.