Alcohol bottles at a bar
Epigenome Editing Decreases Alcohol Seeking and Anxiety in Rats
A CRISPR-based system that reverses epigenetic changes caused by adolescent binge drinking reduces adult addiction-like behaviors in rats, a study finds, suggesting that an epigenomic approach could someday help treat people with alcohol use disorder.
ABOVE: © iStock.com, Semen Salivanchuk
Epigenome Editing Decreases Alcohol Seeking and Anxiety in Rats
Epigenome Editing Decreases Alcohol Seeking and Anxiety in Rats

A CRISPR-based system that reverses epigenetic changes caused by adolescent binge drinking reduces adult addiction-like behaviors in rats, a study finds, suggesting that an epigenomic approach could someday help treat people with alcohol use disorder.

A CRISPR-based system that reverses epigenetic changes caused by adolescent binge drinking reduces adult addiction-like behaviors in rats, a study finds, suggesting that an epigenomic approach could someday help treat people with alcohol use disorder.

ABOVE: © iStock.com, Semen Salivanchuk

gene editing

close-up of an Aedes aegypti mosquito on human skin
Researchers Discover What Attracts Mosquitoes to Humans
Sophie Fessl | May 11, 2022
A brain area of Aedes aegypti responds specifically to components of human sebum, a study finds.
An orange CRISPR Cas 9 enzyme cutting DNA
CRISPR-Based Treatment Successfully Lowers Toxic Protein Levels
Natalia Mesa | Mar 2, 2022
A first-of-its-kind gene therapy dramatically reduced misfolded protein levels in some clinical trial participants for up to six months and reduced levels in all participants for up to a year.
The Past, Present, and Future of Cell and Gene Therapy
The Past, Present, and Future of Cell and Gene Therapy
The Scientist Creative Services Team, Bio-Rad Laboratories | Dec 23, 2021
Embark on the journey of cell and gene therapy—from its conception and development, to its present state, and into its future.
Vector illustration of a courthouse with test tubes as pillars
CRISPR Patent Ruling Favors Broad Institute
Jef Akst | Mar 1, 2022
The US Patent and Trademark Office has once again decided that the institute has priority over the University of California and collaborators regarding intellectual property rights for CRISPR-Cas9 gene editing in eukaryotes. But the fight over the technique isn’t over.
DNA
In Editing RNA, Researchers See Endless Possibilities
Christie Wilcox | Dec 1, 2021
RNA editing has been in DNA editing’s shadow for nearly a decade, but recent investments in the technology could bring it into the limelight.
Challenges and Applications
Combinatorial Single Cell CRISPR Screens: Challenges and Applications
The Scientist Creative Services Team in collaboration with 10x Genomics | Dec 10, 2021
An expert panel will discuss how single cell sequencing enhances throughput in CRISPR gene editing applications.
Infographic showing endogenous adenosine enzymes acting on RNA (ADARs) edit genetic material in the cell by attaching to naturally occurring double-stranded RNAs, including mRNAs, and switching out A bases with I bases (left). Therapeutic RNA editing platforms based on this mechanism fall into one of two categories: either they use engineered enzymes, which generally consist of the editing part of the ADAR enzyme attached to another protein such as Cas13 that boosts specificity, alongside a guide RNA that targets the enzyme to the desired location (middle); or they consist of a guide RNA alone, which recruits an endogenous ADAR to edit the target sequence (right).
Infographic: RNA Editing Approaches
Christie Wilcox | Dec 1, 2021
RNA editing platforms leverage the natural activity of ADAR enzymes to make key changes to messenger RNAs before they are translated into proteins.
Lizard on glass tank
Engineered Stem Cells Grant Geckos “Perfectly” Regenerated Tails
Chloe Tenn | Nov 5, 2021
Geckos injected with neural stem cells modified to block cartilage growth developed the skeletal and nervous components normally lacking from regrown tails.
CRISPR for Genome Engineering in Drosophila
Technique Talk: CRISPR for Genome Engineering in Drosophila
The Scientist Creative Services Team | Nov 30, 2021
Discover how CRISPR is revolutionizing gene editing in a classic genetics research model.
cartoon depiction of a pair of scissors about to cut a DNA double helix
Researchers Uncover New Families of Gene-Editing Enzymes
Annie Melchor | Sep 15, 2021
The results reveal evolutionary relatives of the Cas9 enzyme now used extensively in biotechnology.
Hong Kong skyline with a pink sky in the background
Book excerpt from CRISPR People
Henry T. Greely | Aug 1, 2021
In Chapter 6, author Henry T. Greely describes how news of the birth of gene-edited babies rocked a 2018 summit on human genome editing.
untitled-design
From Bench to Boardroom
Aparna Nathan | Oct 25, 2021
Taking inspiration from her PhD research, Ana Moreno formed a company where scientists use CRISPR to treat chronic pain
Opinion: How Biomedicine Could Transform Human Reproduction
Henry T. Greely | Aug 1, 2021
CRISPR and other innovations are likely to open up a wealth of new options for how people have children.
cartoon showing a hand taking a tool to a double-helix of DNA to represent gene editing
WHO Releases New Recommendations on Human Genome Editing
Annie Melchor | Jul 12, 2021
The guidance comes after two years of consulting with hundreds of stakeholders, including indigenous peoples, religious leaders, patient groups, and scientists.
800-x-560-sept-tss
The Scientist Speaks - Homing in on New Anticancer Targets 
Sejal Davla, PhD | Sep 28, 2021
Jason Sheltzer discusses cancer mechanisms leading to drug resistance and new approaches to find drug targets.
CRISPR, Cas-9, Nobel, Chemistry
CRISPR’s Adaptation to Genome Editing Earns Chemistry Nobel
Amanda Heidt | Oct 7, 2020
Emmanuelle Charpentier and Jennifer Doudna reprogrammed the bacterial immune response into one of the most popular tools for genetics and molecular biology.
Panel Lays Out Guidelines for CRISPR-Edited Human Embryos
Lisa Winter | Sep 4, 2020
The International Commission on the Clinical Use of Human Germline Genome Editing claims the technology is still too risky for therapeutic use.
38630-tsu-redefiningmousetransgenesis-webinarbanners-800x560
Technique Talk: Redefining Mouse Transgenesis with CRISPR-Cas Technology
The Scientist Creative Services Team | Aug 9, 2021
Learn how CRISPR-Cas technology has revolutionized the creation of transgenic mouse models.
CRISPR, TALENs, ZFNs, gene editing, base editing, mitochondria, DNA, mtDNA
New Gene Editing Tool Corrects Mutations in Mitochondrial DNA
Amanda Heidt | Jul 9, 2020
An enzyme pulled from toxic bacteria can enter the organelle and perform single-nucleotide DNA swaps.