A gloved hand holds a tweezer and pulls a section of DNA away from a double helix
First Person Dosed in Novel Gene Editing Clinical Trial
The biotech company Verve Therapeutics launched the study with the aim of using base editing to treat a genetic condition that causes high cholesterol and increases a person's risk of developing cardiovascular disease.
First Person Dosed in Novel Gene Editing Clinical Trial
First Person Dosed in Novel Gene Editing Clinical Trial

The biotech company Verve Therapeutics launched the study with the aim of using base editing to treat a genetic condition that causes high cholesterol and increases a person's risk of developing cardiovascular disease.

The biotech company Verve Therapeutics launched the study with the aim of using base editing to treat a genetic condition that causes high cholesterol and increases a person's risk of developing cardiovascular disease.

CRISPR/Cas
Green-tinged image of fly eye with shiny and black portions
New CRISPR Technique Causes Few Unintended Mutations in Fruit Flies
Jason P. Dinh | Jul 1, 2022
A study finds that CRISPR-Nickase, which changes just one allele of a given gene, improves gene editing efficiency compared with CRISPR-Cas9.
an artistic rendering of CRISPR/Cas9
Ten Years of CRISPR
Sophie Fessl | Jun 28, 2022
This month marks ten years since CRISPR-Cas9 was repurposed as a gene editing system, so we’re looking back at what has been accomplished in a decade of CRISPR editing.
CRISPR Biosensors for Disease Diagnostics
The Scientist Creative Services Team
Kiana Aran and Can Dincer will discuss potential advantages and diagnostic applications of CRISPR biosensing.
An orange CRISPR Cas 9 enzyme cutting DNA
CRISPR-Based Treatment Successfully Lowers Toxic Protein Levels
Natalia Mesa | Mar 2, 2022
A first-of-its-kind gene therapy dramatically reduced misfolded protein levels in some clinical trial participants for up to six months and reduced levels in all participants for up to a year.
Lizard on glass tank
Engineered Stem Cells Grant Geckos “Perfectly” Regenerated Tails
Chloe Tenn | Nov 5, 2021
Geckos injected with neural stem cells modified to block cartilage growth developed the skeletal and nervous components normally lacking from regrown tails.
The Scientist's LabTalk Podcast - Episode 2
The Scientist Creative Services Team
Surviving Stress: The mysteries of neuronal survival and neurodegeneration
Hong Kong skyline with a pink sky in the background
Book excerpt from CRISPR People
Henry T. Greely | Aug 1, 2021
In Chapter 6, author Henry T. Greely describes how news of the birth of gene-edited babies rocked a 2018 summit on human genome editing.
Panel Lays Out Guidelines for CRISPR-Edited Human Embryos
Lisa Winter | Sep 4, 2020
The International Commission on the Clinical Use of Human Germline Genome Editing claims the technology is still too risky for therapeutic use.
gene, CRISPR, CRISPR-Cas9, gene editing, human embryo, chromosome, mutation, deletion
CRISPR Gene Editing Prompts Chaos in DNA of Human Embryos
Amanda Heidt | Jun 26, 2020
Three studies identify unintended consequences of gene editing in human embryos, including large deletions and reshuffling of DNA.
Symptoms in ALS Mouse Model Improve with CRISPR Base Editing
Abby Olena | Apr 10, 2020
Researchers slowed disease progression in the mice by injecting two different viral vectors, each containing one part of the DNA encoding the Cas9 protein, to edit the causative gene.
Infographic: CRISPR’d Cancer
Rachael Moeller Gorman | Apr 1, 2020
Researchers use a new way to deliver CRISPR/Cas9 to tumors in mice, wiping out the cancer.
an illustration of a single cell with a backdrop of similar cells
The Advances that Will Shape Life Sciences in the 2020s
Emma Yasinski | Jan 3, 2020
Systems biologist Steven Wiley says advancements in two areas—single-cell biology and CRISPR—are poised to transform research.  
an illustration of Toxoplasma gondii parasites infecting cells
Top Technical Advances of 2019
Shawna Williams | Dec 24, 2019
From artificial intelligence to pluripotent stem cells, this year saw the publication of a bevy of intriguing new methods, as well as tweaks to existing protocols.
CRISPR-Based Tool Expands DNA-Hydrogel Versatility
Ruth Williams | Dec 1, 2019
DNA-responsive polymer gels used for releasing drugs, encapsulating cells, and much more now have greater adaptability thanks to the Cas12a nuclease.
Infographic: Sequence-Directed Gel Degradation
Ruth Williams | Dec 1, 2019
A novel system for customizable DNA-hydrogel manipulations
A Brief Guide to the Current CRISPR Landscape
Diana Kwon | Jul 15, 2019
Hundreds of CRISPR patents have been granted around the world, and the number of applications continues to grow at a rapid pace.
crispr dna detection
Infographic: DNA Detection with a Chip
Ruth Williams | Jul 15, 2019
Researchers combine CRISPR technology with a graphene transistor to create an electronic sensor for particular DNA sequences.
modus operandi
Digital DNA Detection
Ruth Williams | Jul 15, 2019
A CRISPR-based electronic sensor flags target DNA sequences at high speed.
USPTO Restarts CRISPR Patent Dispute Between Broad and UC
Jef Akst | Jun 26, 2019
The US patent office declares an interference between the intellectual property held by the Broad Institute and several patent applications filed by the University of California—opposite its previous ruling.