A CRISPR-Cas9 enzyme (orange) cutting a DNA strand (blue)
CRISPR-Based Treatment Successfully Lowers Toxic Protein Levels
A first-of-its-kind gene therapy dramatically reduced misfolded protein levels in some clinical trial participants for up to six months and reduced levels in all participants for up to a year.
ABOVE: © iStock.com, Design Cells
CRISPR-Based Treatment Successfully Lowers Toxic Protein Levels
CRISPR-Based Treatment Successfully Lowers Toxic Protein Levels

A first-of-its-kind gene therapy dramatically reduced misfolded protein levels in some clinical trial participants for up to six months and reduced levels in all participants for up to a year.

A first-of-its-kind gene therapy dramatically reduced misfolded protein levels in some clinical trial participants for up to six months and reduced levels in all participants for up to a year.

ABOVE: © iStock.com, Design Cells

CRISPR/Cas

Lizard on glass tank
Engineered Stem Cells Grant Geckos “Perfectly” Regenerated Tails
Chloe Tenn | Nov 5, 2021
Geckos injected with neural stem cells modified to block cartilage growth developed the skeletal and nervous components normally lacking from regrown tails.
Hong Kong skyline with a pink sky in the background
Book excerpt from CRISPR People
Henry T. Greely | Aug 1, 2021
In Chapter 6, author Henry T. Greely describes how news of the birth of gene-edited babies rocked a 2018 summit on human genome editing.
CRISPR Biosensors for Disease Diagnostics
The Scientist Creative Services Team | Feb 2, 2021
Kiana Aran and Can Dincer will discuss potential advantages and diagnostic applications of CRISPR biosensing.
Panel Lays Out Guidelines for CRISPR-Edited Human Embryos
Lisa Winter | Sep 4, 2020
The International Commission on the Clinical Use of Human Germline Genome Editing claims the technology is still too risky for therapeutic use.
gene, CRISPR, CRISPR-Cas9, gene editing, human embryo, chromosome, mutation, deletion
CRISPR Gene Editing Prompts Chaos in DNA of Human Embryos
Amanda Heidt | Jun 26, 2020
Three studies identify unintended consequences of gene editing in human embryos, including large deletions and reshuffling of DNA.
The Scientist's LabTalk Podcast - Episode 2
The Scientist Creative Services Team | Oct 20, 2020
Surviving Stress: The mysteries of neuronal survival and neurodegeneration
Symptoms in ALS Mouse Model Improve with CRISPR Base Editing
Abby Olena | Apr 10, 2020
Researchers slowed disease progression in the mice by injecting two different viral vectors, each containing one part of the DNA encoding the Cas9 protein, to edit the causative gene.
Infographic: CRISPR’d Cancer
Rachael Moeller Gorman | Apr 1, 2020
Researchers use a new way to deliver CRISPR/Cas9 to tumors in mice, wiping out the cancer.
an illustration of a single cell with a backdrop of similar cells
The Advances that Will Shape Life Sciences in the 2020s
Emma Yasinski | Jan 3, 2020
Systems biologist Steven Wiley says advancements in two areas—single-cell biology and CRISPR—are poised to transform research.  
an illustration of Toxoplasma gondii parasites infecting cells
Top Technical Advances of 2019
Shawna Williams | Dec 24, 2019
From artificial intelligence to pluripotent stem cells, this year saw the publication of a bevy of intriguing new methods, as well as tweaks to existing protocols.
CRISPR-Based Tool Expands DNA-Hydrogel Versatility
Ruth Williams | Dec 1, 2019
DNA-responsive polymer gels used for releasing drugs, encapsulating cells, and much more now have greater adaptability thanks to the Cas12a nuclease.
Infographic: Sequence-Directed Gel Degradation
Ruth Williams | Dec 1, 2019
A novel system for customizable DNA-hydrogel manipulations
A Brief Guide to the Current CRISPR Landscape
Diana Kwon | Jul 15, 2019
Hundreds of CRISPR patents have been granted around the world, and the number of applications continues to grow at a rapid pace.
crispr dna detection
Infographic: DNA Detection with a Chip
Ruth Williams | Jul 15, 2019
Researchers combine CRISPR technology with a graphene transistor to create an electronic sensor for particular DNA sequences.
modus operandi
Digital DNA Detection
Ruth Williams | Jul 15, 2019
A CRISPR-based electronic sensor flags target DNA sequences at high speed.
USPTO Restarts CRISPR Patent Dispute Between Broad and UC
Jef Akst | Jun 26, 2019
The US patent office declares an interference between the intellectual property held by the Broad Institute and several patent applications filed by the University of California—opposite its previous ruling.
AI
Could AI Make Gene Editing More Accurate?
Ashley Yeager | May 1, 2019
Machine learning algorithms predict the repairs made to DNA after Cas9 cuts.
medilit infographic
Infographic: AI Predicts Post-CRISPR Repairs
Ashley Yeager | May 1, 2019
Double-strand breaks can produce several different outcomes.
CRISPR mice lungs gene genetic editing disease womb fetus
Mice Gene-Edited While Still in the Womb
Chia-Yi Hou | Apr 19, 2019
CRISPR reagents injected into the amniotic fluid inactivated a gene in the fetuses that would normally cause lung disease and kill the mice a few hours after birth.