CRISPR/Cas

The biotech company Verve Therapeutics launched the study with the aim of using base editing to treat a genetic condition that causes high cholesterol and increases a person's risk of developing cardiovascular disease.

A study finds that CRISPR-Nickase, which changes just one allele of a given gene, improves gene editing efficiency compared with CRISPR-Cas9.

This month marks ten years since CRISPR-Cas9 was repurposed as a gene editing system, so we’re looking back at what has been accomplished in a decade of CRISPR editing.

A first-of-its-kind gene therapy dramatically reduced misfolded protein levels in some clinical trial participants for up to six months and reduced levels in all participants for up to a year.

Geckos injected with neural stem cells modified to block cartilage growth developed the skeletal and nervous components normally lacking from regrown tails.

In Chapter 6, author Henry T. Greely describes how news of the birth of gene-edited babies rocked a 2018 summit on human genome editing.

The International Commission on the Clinical Use of Human Germline Genome Editing claims the technology is still too risky for therapeutic use.

Three studies identify unintended consequences of gene editing in human embryos, including large deletions and reshuffling of DNA.

Researchers slowed disease progression in the mice by injecting two different viral vectors, each containing one part of the DNA encoding the Cas9 protein, to edit the causative gene.

Researchers use a new way to deliver CRISPR/Cas9 to tumors in mice, wiping out the cancer.

Systems biologist Steven Wiley says advancements in two areas—single-cell biology and CRISPR—are poised to transform research.  

From artificial intelligence to pluripotent stem cells, this year saw the publication of a bevy of intriguing new methods, as well as tweaks to existing protocols.

DNA-responsive polymer gels used for releasing drugs, encapsulating cells, and much more now have greater adaptability thanks to the Cas12a nuclease.

A novel system for customizable DNA-hydrogel manipulations

Hundreds of CRISPR patents have been granted around the world, and the number of applications continues to grow at a rapid pace.

Researchers combine CRISPR technology with a graphene transistor to create an electronic sensor for particular DNA sequences.