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A gloved hand holds a tweezer and pulls a section of DNA away from a double helix
First Person Dosed in Novel Gene Editing Clinical Trial
The biotech company Verve Therapeutics launched the study with the aim of using base editing to treat a genetic condition that causes high cholesterol and increases a person's risk of developing cardiovascular disease.
First Person Dosed in Novel Gene Editing Clinical Trial
First Person Dosed in Novel Gene Editing Clinical Trial

The biotech company Verve Therapeutics launched the study with the aim of using base editing to treat a genetic condition that causes high cholesterol and increases a person's risk of developing cardiovascular disease.

The biotech company Verve Therapeutics launched the study with the aim of using base editing to treat a genetic condition that causes high cholesterol and increases a person's risk of developing cardiovascular disease.

CRISPR/Cas
Green-tinged image of fly eye with shiny and black portions
New CRISPR Technique Causes Few Unintended Mutations in Fruit Flies
Jason P. Dinh | Jul 1, 2022 | 4 min read
A study finds that CRISPR-Nickase, which changes just one allele of a given gene, improves gene editing efficiency compared with CRISPR-Cas9.
an artistic rendering of CRISPR/Cas9
Ten Years of CRISPR
Sophie Fessl, PhD | Jun 28, 2022 | 7 min read
This month marks ten years since CRISPR-Cas9 was repurposed as a gene editing system, so we’re looking back at what has been accomplished in a decade of CRISPR editing.
Fluorescent microscopy images of cells after being transfected.
Universal Transfection Reagents: Improving Efficiency and Decreasing Cell Toxicity
The Scientist Creative Services Team, MilliporeSigma, and Roche | 4 min read
Researchers optimize their transfection protocols with the ideal transfection reagent that has multiple applications, low cytotoxicity, and high transfection efficiency.
An orange CRISPR Cas 9 enzyme cutting DNA
CRISPR-Based Treatment Successfully Lowers Toxic Protein Levels
Natalia Mesa, PhD | Mar 2, 2022 | 3 min read
A first-of-its-kind gene therapy dramatically reduced misfolded protein levels in some clinical trial participants for up to six months and reduced levels in all participants for up to a year.
Lizard on glass tank
Engineered Stem Cells Grant Geckos “Perfectly” Regenerated Tails
Chloe Tenn | Nov 5, 2021 | 4 min read
Geckos injected with neural stem cells modified to block cartilage growth developed the skeletal and nervous components normally lacking from regrown tails.
CRISPR Biosensors for Disease Diagnostics
The Scientist Creative Services Team | 1 min read
Kiana Aran and Can Dincer will discuss potential advantages and diagnostic applications of CRISPR biosensing.
Hong Kong skyline with a pink sky in the background
Book excerpt from CRISPR People
Henry T. Greely | Aug 1, 2021 | 9 min read
In Chapter 6, author Henry T. Greely describes how news of the birth of gene-edited babies rocked a 2018 summit on human genome editing.
Panel Lays Out Guidelines for CRISPR-Edited Human Embryos
Lisa Winter | Sep 4, 2020 | 2 min read
The International Commission on the Clinical Use of Human Germline Genome Editing claims the technology is still too risky for therapeutic use.
The Scientist's LabTalk Podcast - Episode 2
The Scientist Creative Services Team | 1 min read
Surviving Stress: The mysteries of neuronal survival and neurodegeneration
gene, CRISPR, CRISPR-Cas9, gene editing, human embryo, chromosome, mutation, deletion
CRISPR Gene Editing Prompts Chaos in DNA of Human Embryos
Amanda Heidt | Jun 26, 2020 | 3 min read
Three studies identify unintended consequences of gene editing in human embryos, including large deletions and reshuffling of DNA.
Symptoms in ALS Mouse Model Improve with CRISPR Base Editing
Abby Olena, PhD | Apr 10, 2020 | 4 min read
Researchers slowed disease progression in the mice by injecting two different viral vectors, each containing one part of the DNA encoding the Cas9 protein, to edit the causative gene.
Infographic: CRISPR’d Cancer
Rachael Moeller Gorman | Apr 1, 2020 | 1 min read
Researchers use a new way to deliver CRISPR/Cas9 to tumors in mice, wiping out the cancer.
an illustration of a single cell with a backdrop of similar cells
The Advances that Will Shape Life Sciences in the 2020s
Emma Yasinski | Jan 3, 2020 | 3 min read
Systems biologist Steven Wiley says advancements in two areas—single-cell biology and CRISPR—are poised to transform research.  
an illustration of Toxoplasma gondii parasites infecting cells
Top Technical Advances of 2019
Shawna Williams | Dec 24, 2019 | 3 min read
From artificial intelligence to pluripotent stem cells, this year saw the publication of a bevy of intriguing new methods, as well as tweaks to existing protocols.
CRISPR-Based Tool Expands DNA-Hydrogel Versatility
Ruth Williams | Dec 1, 2019 | 3 min read
DNA-responsive polymer gels used for releasing drugs, encapsulating cells, and much more now have greater adaptability thanks to the Cas12a nuclease.
Infographic: Sequence-Directed Gel Degradation
Ruth Williams | Dec 1, 2019 | 1 min read
A novel system for customizable DNA-hydrogel manipulations
A Brief Guide to the Current CRISPR Landscape
Diana Kwon | Jul 15, 2019 | 5 min read
Hundreds of CRISPR patents have been granted around the world, and the number of applications continues to grow at a rapid pace.
crispr dna detection
Infographic: DNA Detection with a Chip
Ruth Williams | Jul 15, 2019 | 1 min read
Researchers combine CRISPR technology with a graphene transistor to create an electronic sensor for particular DNA sequences.
modus operandi
Digital DNA Detection
Ruth Williams | Jul 15, 2019 | 3 min read
A CRISPR-based electronic sensor flags target DNA sequences at high speed.
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