A Caribbean sun anemone (Stichodactyla helianthus)WIKIMEDIA, OMAR SPENCE PHOTOGRAPHYA slightly modified synthetic version of a peptide found in the toxin of Caribbean sun anemones boosts metabolic activity in obese mice fed a junk-food diet, according to a study published this week (May 27) in the Proceedings of the National Academy of Sciences. The results indicate that the compound, known as Shk-186, which is already a promising drug candidate for the treatment of several autoimmune diseases, could also be developed as a potential treatment for obesity and insulin resistance in humans.
Developed by George Chandy of the University of California, Irvine, and colleagues, Shk-186 potently and specifically blocks the Kv1.3 potassium channel on T-lymphocyte cells, the upregulation of which is implicated in autoimmune diseases. (For more on Shk-186 and other toxin-derived drugs, see our recent story “From Toxins to Therapeutics.”) However, potassium channels control various cellular processes and previous studies had suggested that Kv1.3 might also regulate metabolic rate and body weight, so Chandy decided to see what effects the tailored peptide, which passed Phase 1 safety trials in March, would have on overweight mice.
In tests on mice fed a high-fat, high-sugar diet, treatment with ShK-186 reduced weight gain, white fat deposits, fatty liver, blood cholesterol, and blood sugar, the researchers reported. They think it ...
