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a trio of infant mice, two brown mice on the ends and one white mouse in the middle
Mice Pass Epigenetic Tweaks to Pups
An engineered methylation pattern persisted for four generations of mice, demonstrating transgenerational epigenetic inheritance can occur in mammals.
Mice Pass Epigenetic Tweaks to Pups
Mice Pass Epigenetic Tweaks to Pups

An engineered methylation pattern persisted for four generations of mice, demonstrating transgenerational epigenetic inheritance can occur in mammals.

An engineered methylation pattern persisted for four generations of mice, demonstrating transgenerational epigenetic inheritance can occur in mammals.

obesity

Close-up image of fat cells
A Snapshot of How Obesity Transforms Fat
Aparna Nathan, PhD | Oct 5, 2023 | 3 min read
Spatial methods reveal immune cell formations in fat during early obesity.
a small black mouse sits next to an obese black mouse on a white background
Obesity Protects Against Genital Herpes in Mice, Study Finds
Katherine Irving | Nov 11, 2022 | 3 min read
A high-fat diet induced changes to the animals’ vaginal microbiomes that boosted survival after exposure to the virus.
VAI
Exposed: Environmental Echoes in Health - A Special Podcast Series
The Scientist and Van Andel Institute | 2 min read
Epigenetic experts discuss how environment and diet leave lasting impressions on the human genome.
A cross-section of a mouse hypothalamus, where cells of the arcuate nucleus are shown in bright green at the bottom.
Methylation in Young Brains May Be Key to Obesity: Mouse Study
Alejandra Manjarrez, PhD | Oct 19, 2022 | 4 min read
Epigenetic events, such as methylation, during early brain development in mice occur in genomic regions associated with BMI in humans, according to a new study.
Why gut health matters. Your digestion are important. Horizontal poster. Medical infographic. Stomach function. Editable vector illustration in modern style. Healthcare and scientific concept
Opinion: Splashing Cold Water on Poop Transplants for Weight Loss
Simar Bajaj | Sep 1, 2022 | 4 min read
Gut microbiome–based solutions hold promise for addressing obesity, but are they overhyped?
gray mouse drinking from water bottle in cage
“Feel-Good” Neurons Steer Mice Toward Hydration-Boosting Liquids
Shafaq Zia | Jul 19, 2022 | 3 min read
The cells signal to the brain how hydrating particular beverages are, but it’s not yet clear whether they play a similar role in humans.
A black mouse runs on a yellow and green spinning wheel against a blue background
Exercising During Pregnancy Protects Mouse Offspring
Jack J. Lee | Aug 1, 2021 | 2 min read
Obese mice that exercised while pregnant gave birth to pups that grew up free of the metabolic issues present in the adult young of sedentary obese mothers—possibly by staving off epigenetic changes to a key metabolic gene.
Pharma Looks to Inflammasome Inhibitors as All-Around Therapies
Rachael Moeller Gorman | Apr 1, 2021 | 10+ min read
Many major biopharmaceutical companies are developing or acquiring drugs that target the NLRP3 inflammasome, a large intracellular complex that researchers say can spark inflammation and stoke diseases of lifestyle and aging.
Obesity-Linked Gut Bacteria May Worsen Graft-Versus-Host Disease
Asher Jones | Apr 1, 2021 | 2 min read
Altered gut microbiome composition in obese mice and human patients is linked with severity of disease after bone marrow transplantation, a study found.
brown fat, metabolism, cardiovascular disease, cardiometabolic disease, genetics & genomics, immunology, Q&A, adipose tissue, obesity
Q&A: Brown Fat Linked to Better Cardio and Metabolic Health
Amanda Heidt | Jan 12, 2021 | 5 min read
Paul Cohen of the Rockefeller University describes his study of thousands of people, finding that the energy-burning tissue is tied to a lower risk of for several diseases, including type 2 diabetes, high blood pressure, and heart disease.
Nearly All NYC-Area COVID-19 Hospitalizations Had Comorbidities
Lisa Winter | Apr 24, 2020 | 2 min read
The most common preexisting conditions among the patients were diabetes, obesity, and hypertension.
70 years of disease research graphic
Image of the Day: 70 Years of Disease Research
Amy Schleunes | Jan 21, 2020 | 1 min read
A video chronicles the course of disease research and prompts questions about where scientists may focus their studies in the future.
a mouse on an exercise wheel
Early Epigenetic Changes Regulate Voluntary Exercise in Mice: Study
Emma Yasinski | Dec 7, 2019 | 3 min read
Altering DNA methylation in a particular area of the hypothalamus halved the animals’ voluntary exercise as adults.
Exercise Changes Our Gut Microbes, But How Isn’t Yet Clear
Ashley Yeager | Aug 15, 2019 | 5 min read
Physical activity, independent of diet, shifts the composition of bacteria in the intestines, spurring researchers to search for species that might provide benefits akin to working out.
scientist to watch laura bowers
Laura Bowers Works to Sever the Link Between Obesity and Cancer
Shawna Williams | Jul 15, 2019 | 3 min read
The Purdue University nutrition researcher delves into the details of how fat tissue affects tumors.
Microbe Miner: A Profile of Rob Knight
Anna Azvolinsky | Jun 1, 2019 | 9 min read
Developing computational tools to analyze the reams of microbial sequencing data his lab generates, the UC San Diego microbiologist is a pioneer of microbiome research.
obesity polygenic risk score genetics
Genetic Risk Score Developed for Obesity
Kerry Grens | Apr 18, 2019 | 2 min read
The tool weighs millions of variants to determine how susceptible a person is to becoming obese.
Fat Tissue Can Help Cancer Cells Proliferate, Metastasize
Catherine Offord | Apr 1, 2019 | 3 min read
Researchers disentangle how adipocytes communicate with prostate tumors in mice.
Changes in Height Linked to Increased C-section Rates
Abby Olena, PhD | Feb 6, 2019 | 4 min read
Countries with populations whose average adult height grew late last century are more likely to have high rates of babies delivered surgically.
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