WIKIMEDIA, RAMA
Researchers have created induced pluripotent stem cells (iPSCs) within diverse tissues of live transgenic mice, according to a paper published today (September 11) in Nature. These iPSCs found circulating in the blood of reprogrammed mice produced gene expression signatures characteristic of murine embryonic stem cells. The researchers also found that the in vivo-produced iPSCs were able to form not only all three germ layers—endoderm, ectoderm, and mesoderm—but they also contributed to the placenta-forming trophectoderm—which stem cells isolated from embryos do not generally produce.
“This is a very rich paper,” said George Daley of the Harvard Stem Cell Institute, Children’s Hospital Boston, and the Dana-Farber Cancer Institute, who authored a commentary on the study but did not participate in the research. “It’s very provocative. It raises ...
