New Protocol Advances Toward Lab-Made Universal Red Blood Cells
New Protocol Advances Toward Lab-Made Universal Red Blood Cells
Researchers report a new way of generating the cells from induced pluripotent stem cells in hopes they will one day be used in blood transfusions.
New Protocol Advances Toward Lab-Made Universal Red Blood Cells
New Protocol Advances Toward Lab-Made Universal Red Blood Cells

Researchers report a new way of generating the cells from induced pluripotent stem cells in hopes they will one day be used in blood transfusions.

Researchers report a new way of generating the cells from induced pluripotent stem cells in hopes they will one day be used in blood transfusions.

induced pluripotent stem cell
Oct4, Considered Vital for Creating iPSCs, Actually Isn’t Needed
Oct4, Considered Vital for Creating iPSCs, Actually Isn’t Needed
Emma Yasinski | Nov 8, 2019
Dropping the transcription factor from the four so-called Yamanaka factors reduces the efficiency of inducing the production of stem cells, but the resulting cells are of greater quality.
Bioethicists Concerned over Japan’s Chimera Embryo Regulations
Bioethicists Concerned over Japan’s Chimera Embryo Regulations
Katarina Zimmer | Apr 4, 2019
Many researchers see the move to relax the rules as a welcome change, yet some are worried the revisions don’t take public concerns enough into consideration.
Opinion: Ethical Challenges in Using iPS Cells to Treat Paralysis
Opinion: Ethical Challenges in Using iPS Cells to Treat Paralysis
John D. Loike, Martin Grumet | Mar 7, 2019
Uncertainties about the cells’ risk profiles and the potential for hyping unproven therapies mean scientists and the media must tread carefully.
Stem Cell–Derived Neurons from People with Autism Grow Differently
Stem Cell–Derived Neurons from People with Autism Grow Differently
Jef Akst | Jan 11, 2019
Changes in gene expression also hint at how the brains of people with ASD develop differently from those of other people.
Increasing Number of iPS Cell Therapies Tested in Clinical Trials
Increasing Number of iPS Cell Therapies Tested in Clinical Trials
Katarina Zimmer | Nov 28, 2018
Since their discovery in 2006, induced pluripotent stem cells have been poised to reprogram regenerative medicine. Twelve years on, here’s how far they’ve come.
Parkinson’s Patient Transplanted with Neurons Derived from iPSCs
Parkinson’s Patient Transplanted with Neurons Derived from iPSCs
Ashley P. Taylor | Nov 14, 2018
This is the first time researchers have tested the use of the reprogrammed stem cells in the human brain.
First iPS Cell Trial for Heart Disease Raises Excitement, Concern
First iPS Cell Trial for Heart Disease Raises Excitement, Concern
Katarina Zimmer | Aug 31, 2018
Without knowing the cells’ mechanism of action, researchers question the best way to administer them to patients.
World’s First Commercial iPSC Cell Plant Opens in Japan
World’s First Commercial iPSC Cell Plant Opens in Japan
Jim Daley | Mar 23, 2018
The $340 million, 30,000-square-foot center will produce cells for therapeutic applications.
Stem Cells Made by Modifying the Epigenome with CRISPR
Stem Cells Made by Modifying the Epigenome with CRISPR
Abby Olena | Jan 25, 2018
Researchers use the technique to turn on Oct4 or Sox2 in mouse embryonic fibroblasts and convert them into pluripotent cells. 
Kyoto University Finds Stem Cell Researcher Guilty of Data Fabrication
Kyoto University Finds Stem Cell Researcher Guilty of Data Fabrication
Katarina Zimmer | Jan 24, 2018
The scientist was a member of a stem cell research team led by Nobel laureate Shinya Yamanaka. 
Coriell Institute CEO Dies
Coriell Institute CEO Dies
Kerry Grens | Jan 4, 2018
Michael Christman oversaw the organization’s well-known biobank and pioneered a personalized medicine initiative.
Researchers Make Knockout Stem Cell Lines in One Step
Researchers Make Knockout Stem Cell Lines in One Step
Ruth Williams | Dec 1, 2017
Combining gene editing and stem-cell induction improves efficiency of functional genetic analyses.
Infographic: Combo Method of Stem Cell Generation
Infographic: Combo Method of Stem Cell Generation
Ruth Williams | Nov 30, 2017
Simultaneous exposure to reprogramming and gene-editing plasmids efficiently produces edited pluripotent colonies.
Partial Reprogramming Offers a Way to Generate High Volumes of Progenitor-Like Cells
Partial Reprogramming Offers a Way to Generate High Volumes of Progenitor-Like Cells
Abby Olena | Nov 30, 2017
Activating genes for reprogramming factors for a short time transforms large numbers of differentiated cells into multipotent forms that could be useful for cell-based therapies.
Image of the Day: Purple Podocytes
Image of the Day: Purple Podocytes
The Scientist Staff | May 11, 2017
Using human induced pluripotent stem cells, scientists grew podocytes, cells that attach to the kidney's glomeruli and help filter blood.  
New Resource for Banked iPSCs
New Resource for Banked iPSCs
Aggie Mika | May 11, 2017
Researchers describe hundreds of induced pluripotent stem cell lines from healthy individuals. 
Developing Brains in Dishes
Developing Brains in Dishes
Ashley P. Taylor | Apr 26, 2017
Two studies report methods to mimic human fetal brain development using neurons derived from human induced pluripotent stem cells that form 3-D, brain-like structures. 
Regulators OK Clinical Trials Using Donor Stem Cells
Regulators OK Clinical Trials Using Donor Stem Cells
Kerry Grens | Feb 5, 2017
Japanese health officials approve human experiments to treat macular degeneration with a cell therapy derived from induced pluripotent stem cells.
Study: MicroRNA, Retroviruses Coordinate to Influence Pluripotency
Study: MicroRNA, Retroviruses Coordinate to Influence Pluripotency
Joshua A. Krisch | Jan 13, 2017
Removing a specific miRNA from stem cells may induce the expression of endogenous retroviruses that enable the cells to form extra-embryonic lineages.