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A person moving the hands of a vintage clock backwards.
Synthetic Circuits Reveal the Key to Rewinding the Cellular Clock
Using a circuit-based system, scientists determined the ideal transcription factor levels to promote the successful reprogramming of fibroblasts into induced pluripotent stem cells.
Synthetic Circuits Reveal the Key to Rewinding the Cellular Clock
Synthetic Circuits Reveal the Key to Rewinding the Cellular Clock

Using a circuit-based system, scientists determined the ideal transcription factor levels to promote the successful reprogramming of fibroblasts into induced pluripotent stem cells.

Using a circuit-based system, scientists determined the ideal transcription factor levels to promote the successful reprogramming of fibroblasts into induced pluripotent stem cells.

induced pluripotent stem cell

red blood cell rbc ipsc induced pluripotent stem cell blood tranfsuion bioreactor
New Protocol Advances Toward Lab-Made Universal Red Blood Cells
Diana Kwon | Dec 17, 2020 | 4 min read
Researchers report a new way of generating the cells from induced pluripotent stem cells in hopes they will one day be used in blood transfusions.
oct4 yamanaka factor oskm ips ipsc induced pluripotent stem cell
Oct4, Considered Vital for Creating iPSCs, Actually Isn’t Needed
Emma Yasinski | Nov 8, 2019 | 3 min read
Dropping the transcription factor from the four so-called Yamanaka factors reduces the efficiency of inducing the production of stem cells, but the resulting cells are of greater quality.
A Brief History of Stem Cells
Scientific Breakthroughs with Stem Cells
Nele Haelterman, PhD | 1 min read
Discover the various ways scientists bolster stem cells to understand and cure disease.
japan flag chimera animal research
Bioethicists Concerned over Japan’s Chimera Embryo Regulations
Katarina Zimmer | Apr 4, 2019 | 5 min read
Many researchers see the move to relax the rules as a welcome change, yet some are worried the revisions don’t take public concerns enough into consideration.
Opinion: Ethical Challenges in Using iPS Cells to Treat Paralysis
John D. Loike and Martin Grumet | Mar 7, 2019 | 3 min read
Uncertainties about the cells’ risk profiles and the potential for hyping unproven therapies mean scientists and the media must tread carefully.
Evangelos Kiskinis describes how the patient-derived iPSCs model of epilepsy help predict drug resistance.
The Scientist Speaks - Modeling Epilepsy in a Dish Using Patient-Derived iPSCs
Sejal Davla, PhD | 1 min read
Evangelos Kiskinis describes how the patient-derived iPSCs model of epilepsy help predict drug resistance.
Stem Cell–Derived Neurons from People with Autism Grow Differently
Jef Akst | Jan 11, 2019 | 2 min read
Changes in gene expression also hint at how the brains of people with ASD develop differently from those of other people.
Increasing Number of iPS Cell Therapies Tested in Clinical Trials
Katarina Zimmer | Nov 28, 2018 | 6 min read
Since their discovery in 2006, induced pluripotent stem cells have been poised to reprogram regenerative medicine. Twelve years on, here’s how far they’ve come.
stem cell culture
An Optimized Culture Medium for Induced Pluripotent Stem Cells
The Scientist Creative Services Team in collaboration with Bio-Techne | 2 min read
An animal component-free culture medium provides a safe and robust alternative for maintaining induced pluripotent stem cells.
Parkinson’s Patient Transplanted with Neurons Derived from iPSCs
Ashley P. Taylor | Nov 14, 2018 | 2 min read
This is the first time researchers have tested the use of the reprogrammed stem cells in the human brain.
First iPS Cell Trial for Heart Disease Raises Excitement, Concern
Katarina Zimmer | Aug 31, 2018 | 4 min read
Without knowing the cells’ mechanism of action, researchers question the best way to administer them to patients.
World’s First Commercial iPSC Cell Plant Opens in Japan
Jim Daley | Mar 23, 2018 | 2 min read
The $340 million, 30,000-square-foot center will produce cells for therapeutic applications.
Stem Cells Made by Modifying the Epigenome with CRISPR
Abby Olena, PhD | Jan 25, 2018 | 3 min read
Researchers use the technique to turn on Oct4 or Sox2 in mouse embryonic fibroblasts and convert them into pluripotent cells. 
Kyoto University Finds Stem Cell Researcher Guilty of Data Fabrication
Katarina Zimmer | Jan 24, 2018 | 2 min read
The scientist was a member of a stem cell research team led by Nobel laureate Shinya Yamanaka. 
Coriell Institute CEO Dies
Kerry Grens | Jan 4, 2018 | 2 min read
Michael Christman oversaw the organization’s well-known biobank and pioneered a personalized medicine initiative.
Researchers Make Knockout Stem Cell Lines in One Step
Ruth Williams | Dec 1, 2017 | 3 min read
Combining gene editing and stem-cell induction improves efficiency of functional genetic analyses.
Infographic: Combo Method of Stem Cell Generation
Ruth Williams | Nov 30, 2017 | 1 min read
Simultaneous exposure to reprogramming and gene-editing plasmids efficiently produces edited pluripotent colonies.
Partial Reprogramming Offers a Way to Generate High Volumes of Progenitor-Like Cells
Abby Olena, PhD | Nov 30, 2017 | 3 min read
Activating genes for reprogramming factors for a short time transforms large numbers of differentiated cells into multipotent forms that could be useful for cell-based therapies.
New Resource for Banked iPSCs
Aggie Mika | May 11, 2017 | 1 min read
Researchers describe hundreds of induced pluripotent stem cell lines from healthy individuals. 
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