New England Biolabs (NEB®) announces the release of the Faustovirus Capping Enzyme (FCE), an mRNA capping solution that combines high activity and a broad temperature range to support mRNA therapeutic manufacturing needs.
As a single-subunit enzyme, FCE contains all the enzymatic activities to achieve a Cap-0 structure, a critical step in eukaryotic mRNA maturation. When used in conjunction with NEB's mRNA Cap 2´-O-Methyltransferase, users can generate a Cap-1 structure in a one-pot reaction.
"The biological versatility of mRNA continues to propel its rise as a therapeutic modality within infectious disease, oncology and beyond," said Breton Hornblower, Product Portfolio Manager at NEB. "We are very excited to introduce FCE – an enzyme discovered at NEB – to our portfolio of products for mRNA synthesis. This new product offers a streamlined, scalable, and cost-effective solution for mRNA capping for both research and therapeutic applications."
"For large-scale mRNA production, I have always favored ...
