A new contract research laboratory operated by France-based NovAliX will provide pharmaceutical companies with access to high-resolution cryo-transmission electron microscopy (cryo-TEM) by Thermo Fisher Scientific for facilitating small molecule and biologic drug discovery. NovAliX’s new laboratory will use the cryo-TEM to provide two-dimensional (2D) and three-dimensional (3D) characterization of small molecule and biological samples. NovAliX has completed its first program with a Japanese pharmaceutical customer. It has multiple projects planned with additional customers, including some of the top pharmaceutical companies.
“Cryo-TEM has great potential in drug discovery applications; it is highly complementary to traditional methods, such as x-ray crystallography and nuclear magnetic resonance,” said Denis Zeyer, CEO, NovAliX. “For small molecules research, cryo-TEM provides structural information about multi-protein complexes or membrane proteins. For biologics, cryo-TEM can deliver critical information about antibody selection, epitope mapping and formulation. This information helps the drug discovery process to become more consistent and reproducible, which ...
