Power Failure

Does mitochondrial dysfunction lie at the heart of common, complex diseases like cancer and autism?

Written byMegan Scudellari
| 12 min read

Register for free to listen to this article
Listen with Speechify
0:00
12:00
Share

KEVIN HAND

Mitochondria are tiny. A single human cell can contain hundreds to thousands of these potato-shaped organelles, depending on the tissue type. They power the biochemical reactions in our cells through the production of adenosine triphosphate (ATP).

These oft-overlooked furnaces, not studied in earnest until the 1970s, are now the subject of intense scrutiny for their potentially central role in common, complex diseases. They may be, scientists say, pivotal to the etiology of diseases such as cancer and Alzheimer’s, epidemics against which researchers and companies have spent billions of dollars but made arguably little progress.

But not everyone agrees with the mitochondrial hypothesis. Complex diseases are simply that, some researchers argue—complex. While mitochondria are essential to human physiology, there has not been sufficient evidence to prove ...

Interested in reading more?

Become a Member of

The Scientist Logo
Receive full access to more than 35 years of archives, as well as TS Digest, digital editions of The Scientist, feature stories, and much more!
Already a member? Login Here
July Digest 2025
July 2025, Issue 1

What Causes an Earworm?

Memory-enhancing neural networks may also drive involuntary musical loops in the brain.

View this Issue
Screening 3D Brain Cell Cultures for Drug Discovery

Screening 3D Brain Cell Cultures for Drug Discovery

Explore synthetic DNA’s many applications in cancer research

Weaving the Fabric of Cancer Research with Synthetic DNA

Twist Bio 
Illustrated plasmids in bright fluorescent colors

Enhancing Elution of Plasmid DNA

cytiva logo
An illustration of green lentiviral particles.

Maximizing Lentivirus Recovery

cytiva logo

Products

sartorius-logo

Introducing the iQue 5 HTS Platform: Empowering Scientists  with Unbeatable Speed and Flexibility for High Throughput Screening by Cytometry

parse_logo

Vanderbilt Selects Parse Biosciences GigaLab to Generate Atlas of Early Neutralizing Antibodies to Measles, Mumps, and Rubella

shiftbioscience

Shift Bioscience proposes improved ranking system for virtual cell models to accelerate gene target discovery

brandtechscientific-logo

BRANDTECH Scientific Launches New Website for VACUU·LAN® Lab Vacuum Systems