Low levels of a biochemical process involved in fat breakdown predicts weight gain and metabolic complications more than a decade later.

Viewing oncogenic mutations in 3-D showed that they cluster together on folded proteins.

Findings from a randomized, controlled trial finds that reducing food intake decreases metabolism and reduces oxidative damage to tissues and cells.

Millions of measurements from 23 people who consumed extra calories every day for a month reveal changes in proteins, metabolites, and gut microbiota that accompany shifts in body mass.

Emerging technologies help researchers draw mechanistic links between metabolism and epigenetic modification of DNA.

Maintaining dynamic connections among the body’s mitochondria is required for the health and life-extending benefits of low-calorie diets for nematodes.

Asprosin—involved in a rare disease called neonatal progeroid syndrome—targets neurons to stimulate appetite, and blocking the hormone wards off weight gain in rodents.

Animals lacking a sense of smell stayed thinner than their smelling counterparts, despite eating the same amount.

Data point to peaks in gene expression in the morning and evening that are distinct from day-night circadian cycles.

Regularly taking breaks from eating—for hours or days—can trigger changes both expected, such as in metabolic dynamics and inflammation, and surprising, as in immune system function and cancer progression.