Smell May Be Possible Without Olfactory Bulbs

A study identifies five women who have a functioning sense of smell despite an apparent lack of olfactory bulbs—the region of the brain that processes odors.

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Some women who lack olfactory bulbs seem to be able to smell without a problem, according to a study published today (November 6) in Neuron. The finding is a surprise to neuroscientists, who have considered the brain structures to be the sites of scent processing.

When odors enter the nose and trigger chemical receptors there, electrical signals travel to the olfactory bulbs of the brain, where clusters of nerves called glomeruli process the smell’s signal. Without olfactory bulbs, a person should be unable to process odors, researchers had assumed.

In a study of healthy, left-handed women, neuroscientist Noam Sobel of the Weizmann Institute of Science in Rehovot, Israel, and colleagues happened to identify two women who appeared to lack olfactory bulbs. But when they conducted an odor test, the women showed no impairments to their sense of smell.

Turning to MRI scans of more than 1,000 ...

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Meet the Author

  • Jef Akst

    Jef Akst was managing editor of The Scientist, where she started as an intern in 2009 after receiving a master’s degree from Indiana University in April 2009 studying the mating behavior of seahorses.
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