South African SARS-CoV-2 Variant Alarms Scientists

An additional mutation in the spike protein of the coronavirus may help it elude antibody recognition, and scientists are investigating if current vaccines will protect against it.

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ABOVE: Cape Town, South Africa, in April, 2020. The variant was first discovered in the Eastern Cape province and reported by the country’s health department on December 18.
© ISTOCK.COM, FIVEPOINTSIX

Scientists are testing if COVID-19 vaccines will protect against newly identified UK and South African SARS-CoV-2 variants, both of which contain an unusual number of mutations compared to other variants of the coronavirus. These mutations are concentrated mainly in the segment of the virus’s genome that codes for the spike protein, which the Pfizer/BioNTech, Moderna, and Oxford-AstraZeneca vaccines each build immunity to.

This additional research comes as British health secretary Matt Hancock says he is more concerned about the South African variant, known as 501.V2, as it relates to vaccine efficacy than the UK variant, known as B.1.1.7.

“One of the reasons they know they’ve got a problem is because, like us, they have an excellent genomic scientific capability ...

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Meet the Author

  • Max Kozlov

    Max is a science journalist from Boston. Though he studied cognitive neuroscience, he now prefers to write about brains rather than research them. Prior to writing for The Scientist as an editorial intern in late 2020 and early 2021, Max worked at the Museum of Science in Boston, where his favorite part of the job was dressing in a giant bee costume and teaching children about honeybees. He was also a AAAS Mass Media Fellow, where he worked as a science reporter for the St. Louis Post-Dispatch. Read more of his work at www.maxkozlov.com.

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