Sticky Lithography

Scotch tape and a scalpel provide a MacGyver-esque approach to microfabrication.

Written byRuth Williams
| 2 min read

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Researchers may be able to ditch the expensive photolithography equipment used for making microfluidic flow cells and cell-patterning devices designed to study cellular spatial organization. Scotch tape and a scalpel are all that’s needed, says Raquel Perez-Castillejos, a biomedical engineer at the New Jersey Institute of Technology in Newark.

Typically, researchers use photolithographic technology to fabricate the tiny chambers and channels used in microfluidic devices, or wells for depositing cells onto specific parts of culture dishes and slides. However, the equipment can be expensive, and generally needs to be housed in dust-free facilities, which are not readily available to all researchers.

Perez-Castillejos realized that such a sophisticated and precise apparatus was not essential for tackling many research questions. “Sometimes we are trying to provide very ...

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  • ruth williams

    Ruth is a freelance journalist. Before freelancing, Ruth was a news editor for the Journal of Cell Biology in New York and an assistant editor for Nature Reviews Neuroscience in London. Prior to that, she was a bona fide pipette-wielding, test tube–shaking, lab coat–shirking research scientist. She has a PhD in genetics from King’s College London, and was a postdoc in stem cell biology at Imperial College London. Today she lives and writes in Connecticut.

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