New “Prime Editing” Method Makes Only Single-Stranded DNA Cuts
New “Prime Editing” Method Makes Only Single-Stranded DNA Cuts
In demonstrations in cell lines, the technique has a similar efficacy to CRISPR-Cas9, but fewer off-target effects.
New “Prime Editing” Method Makes Only Single-Stranded DNA Cuts
New “Prime Editing” Method Makes Only Single-Stranded DNA Cuts

In demonstrations in cell lines, the technique has a similar efficacy to CRISPR-Cas9, but fewer off-target effects.

In demonstrations in cell lines, the technique has a similar efficacy to CRISPR-Cas9, but fewer off-target effects.

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base editing
Base Editors Cause Off-Target Mutations in RNA
Base Editors Cause Off-Target Mutations in RNA
Catherine Offord | Apr 18, 2019
A new study indicates that the modified CRISPR-Cas9 technology will need to be further refined before it can safely be used for research and therapeutic applications.
Better Base Editing in Plants
Better Base Editing in Plants
Ruth Williams | Jan 31, 2019
Adenine editing enzymes have been adapted for use in plants.
Infographic: Plant Genome Editors Get A New Tool
Infographic: Plant Genome Editors Get A New Tool
Ruth Williams | Jan 31, 2019
Adenine editing enzymes have been adapted for use in plants.
CRISPR Editing Heads Off Disease in Mouse LiversCRISPR Editing Heads Off Disease in Mouse Livers
CRISPR Editing Heads Off Disease in Mouse Livers
Shawna Williams | Oct 9, 2018
Separate proof-of-concept studies report success against two inherited diseases.
Base Editing Now Able to Convert Adenine-Thymine to Guanine-Cytosine
Base Editing Now Able to Convert Adenine-Thymine to Guanine-Cytosine
Catherine Offord | Oct 25, 2017
With the arrival of a new class of single-nucleotide editors, researchers can target the most common type of pathogenic SNP in humans.
Technique Adapted from CRISPR-Cas9 Corrects Mutation in Human Embryos
Technique Adapted from CRISPR-Cas9 Corrects Mutation in Human Embryos
Catherine Offord | Sep 28, 2017
Researchers use base-editing to swap out an erroneous nucleotide responsible for a potentially life-threatening blood disorder.
CRISPR: No Cutting Required
CRISPR: No Cutting Required
Anna Azvolinsky | Aug 4, 2016
Combining a modified Cas9 enzyme with an unrelated one derived from the immune system of the sea lamprey, researchers demonstrate yet another way to edit a single DNA nucleotide. 
Advances in Genome Editing
Advances in Genome Editing
Catherine Offord | Apr 20, 2016
Researchers develop a CRISPR-based technique that efficiently corrects point mutations without cleaving DNA.