Metal and colorful model of RNA
In Editing RNA, Researchers See Endless Possibilities
RNA editing has been in DNA editing’s shadow for nearly a decade, but recent investments in the technology could bring it into the limelight.
ABOVE: © istock.com, Andy
In Editing RNA, Researchers See Endless Possibilities
In Editing RNA, Researchers See Endless Possibilities

RNA editing has been in DNA editing’s shadow for nearly a decade, but recent investments in the technology could bring it into the limelight.

RNA editing has been in DNA editing’s shadow for nearly a decade, but recent investments in the technology could bring it into the limelight.

ABOVE: © istock.com, Andy

base editing

CRISPR, TALENs, ZFNs, gene editing, base editing, mitochondria, DNA, mtDNA
New Gene Editing Tool Corrects Mutations in Mitochondrial DNA
Amanda Heidt | Jul 9, 2020
An enzyme pulled from toxic bacteria can enter the organelle and perform single-nucleotide DNA swaps.
prime editing crispr cas9 genome editing techniques
New “Prime Editing” Method Makes Only Single-Stranded DNA Cuts
Emma Yasinski | Oct 21, 2019
In demonstrations in cell lines, the technique has a similar efficacy to CRISPR-Cas9, but fewer off-target effects.
a target surrounded by arrows that missed
Base Editors Cause Off-Target Mutations in RNA
Catherine Offord | Apr 18, 2019
A new study indicates that the modified CRISPR-Cas9 technology will need to be further refined before it can safely be used for research and therapeutic applications.
MO
Better Base Editing in Plants
Ruth Williams | Feb 1, 2019
Adenine editing enzymes have been adapted for use in plants.
MO infographic
Infographic: Plant Genome Editors Get A New Tool
Ruth Williams | Feb 1, 2019
Adenine editing enzymes have been adapted for use in plants.
CRISPR Editing Heads Off Disease in Mouse Livers
Shawna Williams | Oct 9, 2018
Separate proof-of-concept studies report success against two inherited diseases.
Base Editing Now Able to Convert Adenine-Thymine to Guanine-Cytosine
Catherine Offord | Oct 25, 2017
With the arrival of a new class of single-nucleotide editors, researchers can target the most common type of pathogenic SNP in humans.
Technique Adapted from CRISPR-Cas9 Corrects Mutation in Human Embryos
Catherine Offord | Sep 28, 2017
Researchers use base-editing to swap out an erroneous nucleotide responsible for a potentially life-threatening blood disorder.
CRISPR: No Cutting Required
Anna Azvolinsky | Aug 4, 2016
Combining a modified Cas9 enzyme with an unrelated one derived from the immune system of the sea lamprey, researchers demonstrate yet another way to edit a single DNA nucleotide. 
Advances in Genome Editing
Catherine Offord | Apr 20, 2016
Researchers develop a CRISPR-based technique that efficiently corrects point mutations without cleaving DNA.