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Two scissors cutting separate strands of a DNA molecule.
Genotoxic Effects of Base and Prime Editing
A risk-benefit analysis of gene editing tools in stem cells revealed that base and prime editing carry vulnerabilities similar to those of CRISPR-Cas9, but at a reduced rate. 
Genotoxic Effects of Base and Prime Editing
Genotoxic Effects of Base and Prime Editing

A risk-benefit analysis of gene editing tools in stem cells revealed that base and prime editing carry vulnerabilities similar to those of CRISPR-Cas9, but at a reduced rate. 

A risk-benefit analysis of gene editing tools in stem cells revealed that base and prime editing carry vulnerabilities similar to those of CRISPR-Cas9, but at a reduced rate. 

base editing

Artist’s impression of stem cells. The cells have a transparent cell membrane on a pale blue background.
Overcoming Cancer Therapy Obstacles With Epitope Editing
Rebecca Roberts, PhD | Oct 12, 2023 | 3 min read
Editing epitopes expressed on the surfaces of transplanted hematopoietic stem cells renders them resistant to AML treatments without affecting their critical functions.
Medical illustration of a scientist replacing part of a DNA molecule with tweezers, representing genome editing.
On the Hunt for the Next Breakthrough in Motor Neuron Disease
Deanna MacNeil, PhD | May 9, 2023 | 3 min read
Researchers leave no stone unturned in the search for a spinal muscular atrophy treatment strategy that uses base editing.
Molecular illustration of CRISPR editing the DNA double helix
Prime Time Precision with CRISPR Technologies
The Scientist | 1 min read
Base editors and prime editors help researchers perform more precise in vivo and ex vivo translational research.
Cas9 enzyme
Molecular Glue ‘Shreds’ Cas9 and Enables a New Form of CRISPR Control
Ida Emilie Steinmark, PhD | Apr 26, 2023 | 3 min read
In a bid to address safety concerns about immune reactions during treatment with CRISPR-based therapeutics, a new technique speeds up how quickly the body destroys the DNA-cutting enzyme Cas9.
Illustration of DNA
Can “Gene Writing” Deliver What Gene Editing Can’t?
Dan Robitzski | Dec 12, 2022 | 10+ min read
A biotech startup called Tessera Therapeutics has made a splash with its claims about the trademarked technology. Is the excitement justified?
3D structural model of a Cas protein and sgRNA targeting and unwinding DNA for gene editing.
CRISPR Gene Editing: Cas9 and Beyond
Johanna Pruller, PhD and Deanna MacNeil, PhD | 7 min read
Researchers create and improve CRISPR-Cas mediated gene editing technologies based on prokaryotic CRISPR systems and eukaryotic DNA repair mechanisms.
3D representation of a DNA helix and with a base offset from the main helix, illustrating the concept of base editing.
A CRISPR Alternative for Correcting Mutations That Sensitize Cells to DNA Damage
Deanna MacNeil, PhD | Oct 10, 2022 | 3 min read
Researchers turned to base editors to correct mutations causing the rare genetic disease Fanconi anemia without inducing double-strand DNA breaks.
A gloved hand holds a tweezer and pulls a section of DNA away from a double helix
First Person Dosed in Novel Gene Editing Clinical Trial
Amanda Heidt | Jul 12, 2022 | 4 min read
The biotech company Verve Therapeutics launched the study with the aim of using base editing to treat a genetic condition that causes high cholesterol and increases a person's risk of developing cardiovascular disease.
David Liu
Targeting a Genetic Accident to Treat Disease
Deanna MacNeil, PhD | 2 min read
David Liu shares how integrating chemistry and evolution in his research has directed his work on base editing techniques aimed at developing new therapeutics.
DNA
In Editing RNA, Researchers See Endless Possibilities
Christie Wilcox, PhD | Dec 1, 2021 | 10 min read
RNA editing has been in DNA editing’s shadow for nearly a decade, but recent investments in the technology could bring it into the limelight.
CRISPR, TALENs, ZFNs, gene editing, base editing, mitochondria, DNA, mtDNA
New Gene Editing Tool Corrects Mutations in Mitochondrial DNA
Amanda Heidt | Jul 9, 2020 | 3 min read
An enzyme pulled from toxic bacteria can enter the organelle and perform single-nucleotide DNA swaps.
Technique Talk: Understanding Cancer One Base Edit at a Time
Technique Talk: Understanding Cancer One Base Edit at a Time
The Scientist | 1 min read
Francisco J. Sánchez-Rivera will discuss strategies to design CRISPR base editor libraries for in vivo applications.
prime editing crispr cas9 genome editing techniques
New “Prime Editing” Method Makes Only Single-Stranded DNA Cuts
Emma Yasinski | Oct 21, 2019 | 4 min read
In demonstrations in cell lines, the technique has a similar efficacy to CRISPR-Cas9, but fewer off-target effects.
a target surrounded by arrows that missed
Base Editors Cause Off-Target Mutations in RNA
Catherine Offord | Apr 18, 2019 | 2 min read
A new study indicates that the modified CRISPR-Cas9 technology will need to be further refined before it can safely be used for research and therapeutic applications.
MO
Better Base Editing in Plants
Ruth Williams | Feb 1, 2019 | 3 min read
Adenine editing enzymes have been adapted for use in plants.
MO infographic
Infographic: Plant Genome Editors Get A New Tool
Ruth Williams | Feb 1, 2019 | 1 min read
Adenine editing enzymes have been adapted for use in plants.
CRISPR Editing Heads Off Disease in Mouse Livers
Shawna Williams | Oct 9, 2018 | 2 min read
Separate proof-of-concept studies report success against two inherited diseases.
Base Editing Now Able to Convert Adenine-Thymine to Guanine-Cytosine
Catherine Offord | Oct 25, 2017 | 8 min read
With the arrival of a new class of single-nucleotide editors, researchers can target the most common type of pathogenic SNP in humans.
Technique Adapted from CRISPR-Cas9 Corrects Mutation in Human Embryos
Catherine Offord | Sep 28, 2017 | 2 min read
Researchers use base-editing to swap out an erroneous nucleotide responsible for a potentially life-threatening blood disorder.
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