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A scientist in a laboratory looks surprised. She holds a tube in one hand.
A Miscalculated Step
As a graduate student, Tharin Blumenschein learned that too much sodium hydroxide breaks down more than just bacterial cells.
A Miscalculated Step
A Miscalculated Step

As a graduate student, Tharin Blumenschein learned that too much sodium hydroxide breaks down more than just bacterial cells.

As a graduate student, Tharin Blumenschein learned that too much sodium hydroxide breaks down more than just bacterial cells.

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Binding affinity

Abstract illustration of a circuit board.
Overcoming Roadblocks in PROTAC Characterizations
NanoTemper Technologies | Dec 11, 2023 | 1 min read
Researchers require an accurate and high throughput method to evaluate proteolysis targeting chimera (PROTAC) interactions. 
Abstract waves in red, orange, blue, and purple on a black background.
A Quick and Efficient Strategy for Affinity Screening
NanoTemper Technologies | Dec 7, 2023 | 1 min read
Researchers assessed the binding affinities of PROTAC binary and ternary complexes with Spectral Shift technology.
Conceptual illustration of molecular interactions.
A Solution for Measuring In-Solution Interactions 
NanoTemper Technologies | Dec 5, 2023 | 1 min read
Scientists used Spectral Shift assays to assess binding affinity and degradation of the oncogene regulator WDR5.
A Y-shaped pink, blue, and light green antibody is in focus on a background of blurred pink and purple color, with other antibodies out of focus in the background.
Phage Display: Finding the One in a Million
Shelby Bradford, PhD | Dec 4, 2023 | 10+ min read
A combinatorial approach enabled high-throughput screening of protein libraries for desired target binding.
An illustration of antibodies floating in solution.
Biotherapeutic Antibodies: Journey from the Benchtop to the Clinic
Cytiva | Aug 29, 2023 | 1 min read
Translational scientists employ surface plasmon resonance (SPR) to make informed decisions when choosing their lead antibody candidates. 
An illustration of caffeine molecules.
Visualizing Molecular Interactions without Labels
Cytiva | Aug 17, 2023 | 1 min read
Researchers use label-free surface plasmon resonance to measure affinity and binding kinetics in real time. 
Affinity versus Avidity: Differentiating Between Binding Phenomena  
Affinity versus Avidity: Differentiating Between Binding Phenomena  
The Scientist | Aug 10, 2023 | 1 min read
In this webinar, Tim Heiseler will discuss the importance of assay design when measuring binding kinetics and affinity values, as well as strategies to mitigate avidity effects.
small-molecule therapeutics treat cancer and other diseases
Scientists Take Aim at Disease-Causing RNAs Using Small-Molecule Drugs
Claire Asher | Apr 1, 2019 | 9 min read
Renewed interest from the biotech industry sparks hope for drugging the nucleic acid to treat cancer and other conditions.
Screening Goes In Silico
Carina Storrs | Feb 1, 2015 | 8 min read
Computational tools take some of the cost—and guesswork—out of drug discovery.
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