Gene-Edited Organoids Explore Neanderthal Brain Function
Gene-Edited Organoids Explore Neanderthal Brain Function
Using CRISPR to swap an archaic variant of the NOVA1 gene into human stem cells, researchers create organoids with neurodevelopmental differences from those carrying modern DNA.
Gene-Edited Organoids Explore Neanderthal Brain Function
Gene-Edited Organoids Explore Neanderthal Brain Function

Using CRISPR to swap an archaic variant of the NOVA1 gene into human stem cells, researchers create organoids with neurodevelopmental differences from those carrying modern DNA.

Using CRISPR to swap an archaic variant of the NOVA1 gene into human stem cells, researchers create organoids with neurodevelopmental differences from those carrying modern DNA.

brain organoids
Reduced Adult Neurogenesis Linked with Alzheimer’s Disease
Reduced Adult Neurogenesis Linked with Alzheimer’s Disease
Abby Olena | Feb 1, 2021
Manipulating the production of new neurons can improve cognition in animal models of the disease, raising the possibility that figuring out a way for humans to make more neurons could make a difference for people with dementia.
New Screening Approach Reveals Novel Regulators of Microcephaly
New Screening Approach Reveals Novel Regulators of Microcephaly
Catherine Offord | Jan 1, 2021
Researchers combine organoids, CRISPR-Cas9, and cellular barcoding technologies to identify genes that influence brain size.
The Many Model Systems of COVID-19
The Many Model Systems of COVID-19
Abby Olena | Nov 4, 2020
Researchers turn to familiar model animals, along with some fresh strategies, to develop countermeasures against SARS-CoV-2 and investigate the biology of infection.
The Scientist Speaks Podcast - Episode 7
The Scientist Speaks Podcast - Episode 7
The Scientist Creative Services Team | Jul 29, 2020
Brains in the Palm of your Hand: 3D Organoid Cell Culture
Photos of the Year
Photos of the Year
Emily Makowski | Dec 26, 2019
From bubbling plants to endangered whales, here are some amazing images from The Scientist in 2019.
Organoids Don’t Accurately Model Human Brain DevelopmentOrganoids Don’t Accurately Model Human Brain Development
Organoids Don’t Accurately Model Human Brain Development
Diana Kwon | Oct 23, 2019
A new study suggests that growing in a stressful environment prevents “brains-in-a-dish” from growing in the same way as their in vivo counterparts.
Human Cortical Organoids Model Neuronal Networks
Human Cortical Organoids Model Neuronal Networks
Abby Olena | Aug 29, 2019
After growing in culture for a few months, the mini-brains produced rhythmic neural activity that strengthened over time.
As Brain Organoids Mature, Ethical Questions Arise
As Brain Organoids Mature, Ethical Questions Arise
Ashley Yeager | Aug 1, 2018
Inserting human “mini-brains” into rodents has the potential to broaden scientists’ understanding of neurological disease, but raises quandaries about consciousness.
Infographic: How to Make a Brain Organoid
Infographic: How to Make a Brain Organoid
Ashley Yeager | Jul 31, 2018
Mini-brains can be grown in culture or printed.