brain organoids

By using antisense oligonucleotides to inhibit a mutated exon associated with Timothy syndrome mutation, researchers restored neuron function.

Paola Arlotta seeks to understand the complex symphony of brain development in vitro by using organoid models.

A 3D variation of pooled CRISPR screens could connect the dots between autism spectrum disorder genetics and cell fate pathways in the developing brain.

Alysson Muotri launched brain organoids into outer space and found that microgravity enriches our understanding of brain development and disease.

Explore the latest developments in brain organoid production.

The organoids could one day be used to treat brain injuries in humans. 

The human cells, engineered to respond to blue light, influenced rat behavior when stimulated.

A single amino acid substitution in a protein causes increased neuron production in the frontal lobes of humans compared to Neanderthals—a tiny difference that could have given our species a cognitive edge, researchers say.

Alysson R. Muotri discusses his launch of brain organoids into outer space and how microgravity enriches our understanding of brain development and disease.

The genes are involved in pacing the development of inhibitory and excitatory neurons. An imbalance in these two types of signaling is thought to play a role in autism.

Removal of the 14-day limit for culturing human embryos is one of the main changes in the revised recommendations from the International Society for Stem Cell Research.

Using CRISPR to swap an archaic variant of the NOVA1 gene into human stem cells, researchers create organoids with neurodevelopmental differences from those carrying modern DNA.

Manipulating the production of new neurons can improve cognition in animal models of the disease, raising the possibility that figuring out a way for humans to make more neurons could make a difference for people with dementia.

Researchers combine organoids, CRISPR-Cas9, and cellular barcoding technologies to identify genes that influence brain size.

Researchers turn to familiar model animals, along with some fresh strategies, to develop countermeasures against SARS-CoV-2 and investigate the biology of infection.

From bubbling plants to endangered whales, here are some amazing images from The Scientist in 2019.