Illustration depicting DNA genetic engineering, purple background with white drawings of internal organs like liver, lung, kidney, brain, intestine, stomach and a red heart featuring two orange DNA helices being cut by labcoat-covered arms and hands, which are holding different instruments to cut the helices.
| 4 min read
Current CRISPR guide RNAs are designed based on European reference genomes, leading to false-negative results in cells from people with African ancestry.

cancer cell lines

electron micrograph of grey cancer cell, with two red T cells stuck to the side

Translation of “Jumping Genes” Creates Cancer Therapy Targets

Red T cell

Jumping Genes Put a Target on Cancerous Cells

Vector image of swarming locusts in a field

Scents and Sense-Abilities: Using Bug Brainpower to Smell Cancer

Blue 3D illustration of X-shaped chromosomes

X Chromosome Silenced in Some Cancers in Males

Artist’s 3D rendering of malignant cancer cells, illustrated in pink, as it would appear under a scanning electron microscope.

Underdog Enzyme Likely Responsible for Mutations in Most Cancers

line illustration of DNA with single-strand break

Cancer Cells Break Own DNA to Defend Against Radiation

Hela cells colored in blue

Henrietta Lacks Estate Sues Thermo Fisher over HeLa Cell Line

A view of the nucleus of a cell with DNA in blue, RNA in pink, and associated proteins in yellow and purple

DNA Methylation Influences Replication and Genome Organization

visualization of p53 protein interacting with its inhibitors MDM2 and MDMX

p53 Unleashes Endogenous Retroviruses to Tackle Tumors: Study

Trending

A close-up image of a fly landing on a dessert

What Happens When a Fly Lands on Your Food? 

Image of an infant’s feet that are visible in a hospital incubator.

Record-Breaking DNA Sequencing Technology Could Transform Newborn Care

Photo of John Calhoun crouches within his rodent utopia-turned-dystopia

Universe 25 Experiment

The World's Densest Bones

Multimedia

Olga Anczukow and Ryan Englander discuss how transcriptome splicing affects immune system function in lung cancer.

Long-Read RNA Sequencing Reveals a Regulatory Role for Splicing in Immunotherapy Responses

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Research Roundtable: The Evolving World of Spatial Biology

Research Roundtable: The Evolving World of Spatial Biology

Image of a woman with her hands across her stomach. She has a look of discomfort on her face. There is a blown up image of her stomach next to her and it has colorful butterflies and gut bacteria all swarming within the gut.
November 2025, Issue 1

Why Do We Feel Butterflies in the Stomach?

These fluttering sensations are the brain’s reaction to certain emotions, which can be amplified or soothed by the gut’s own “bugs".

View this Issue
Olga Anczukow and Ryan Englander discuss how transcriptome splicing affects immune system function in lung cancer.

Long-Read RNA Sequencing Reveals a Regulatory Role for Splicing in Immunotherapy Responses

Pacific Biosciences logo
Research Roundtable: The Evolving World of Spatial Biology

Research Roundtable: The Evolving World of Spatial Biology

Conceptual cartoon image of gene editing technology

Exploring the State of the Art in Gene Editing Techniques

Bio-Rad
Conceptual image of a doctor holding a brain puzzle, representing Alzheimer's disease diagnosis.

Simplifying Early Alzheimer’s Disease Diagnosis with Blood Testing

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EVIDENT Launches Sixth Annual Image of the Year Contest

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10x Genomics Launches the Next Generation of Chromium Flex to Empower Scientists to Massively Scale Single Cell Research