The HIV protein Nef can cause long-term genetic changes that lead to hyperreactive immune cells, according to research in human cells and mice. 

The APOE4 variant causes cholesterol buildup in the cells that make protective fatty sheaths for neurons, possibly helping explain its role in neurodegeneration.

Starving glioblastoma tumors of the cholesterol made by astrocytes could suppress brain cancer progression.

The biotech company Verve Therapeutics launched the study with the aim of using base editing to treat a genetic condition that causes high cholesterol and increases a person's risk of developing cardiovascular disease.

The marine animals have evolved a unique molecular pathway enabling them to use toxins to fight off invaders without poisoning themselves in the process.

A study uncovers a novel connection between the biomolecule and cancer progression.

Researchers link a missense mutation in the B4GALT1 gene to lower levels of LDL cholesterol and the blood clotting factor fibrinogen.

Research in mice and humans points to oxidative stress and inflammation as likely drivers of noise-induced health effects such as hypertension and heart disease.

Sound from cars, aircraft, trains, and other man-made machines is more than just annoying. It increases the risk of cardiovascular disease.

Simoni spent more than four decades at Stanford University as a teacher, researcher, and administrator in the university’s biology department.

The cholesterol-lowering drugs quell inflammation and reverse endothelial tissue damage, hints that they might curb the body’s excessive immune response to SARS-CoV-2 infection.

The pharmaceutical firm is buying The Medicines Company, which recently devoted its efforts into developing the cholesterol-lowering medication.

The authors say their results demonstrate the global benefits of studying African genetics.

Researchers find evidence of neutrophil extracellular traps (NETs), sticky clumps of DNA and protein extruded by neutrophils, holding gallstones together.

From cellular self-digestion to the effects of exercise on the brain, our features editor picks her favorite art custom-made for the magazine.

Even in mice with a busted circadian clock and an unhealthy diet, carefully timed feeding overcomes the rodents’ predispositions for metabolic diseases.

The results could lead to a treatment to lower cholesterol in patients with hypercholesterolemia.