DNA cell on scientific background
Mechanism of a Genome Packaging Machine Discovered
Detailed analyses of cohesin’s movements indicate how this protein complex hauls chromatin fibers to package DNA into loops.
Mechanism of a Genome Packaging Machine Discovered
Mechanism of a Genome Packaging Machine Discovered

Detailed analyses of cohesin’s movements indicate how this protein complex hauls chromatin fibers to package DNA into loops.

Detailed analyses of cohesin’s movements indicate how this protein complex hauls chromatin fibers to package DNA into loops.

chromatin dynamics
The hinge region of cohesin pulls DNA to two head regions, like a person’s hand-to-hand motion of pulling on a rope.
Infographic: How Genome-Packaging Protein Cohesin Handles DNA
Ruth Williams | Jan 17, 2022
The hinge region of cohesin pulls DNA to two head regions, like a person’s hand-to-hand motion of pulling on a rope.
An electron microscopy image of a cell with the nucleolus shown in blue, chromatin in green, and nuclear envelope in red
Aging in Mice Linked to Misexpression of Class of Genes
Sophie Fessl | Dec 21, 2021
Genes lacking a particular structure known as CpG islands tend to go haywire in older cells, a study finds, potentially contributing to key facets of aging. But it’s not yet clear if the relationship is causal.
A semi-translucent hydra, complete with a body column, head, and multiple tentacles, is pictured in front of a gray background.
How Hydras Regenerate Decapitated Heads
Dan Robitzski | Dec 14, 2021
Hydra vulgaris constantly replenish the cells in their heads and grow new ones to reproduce asexually. But gene expression analyses reveal that regenerating a head after an injury is a very different process.
Cigall Kadoch Unravels Chromatin’s Role in Cancer
Chia-Yi Hou | Sep 1, 2019
The Dana-Farber Cancer Institute researcher is developing cancer therapeutics based on how the physical structure of DNA contributes to the disease.
Imaging Chromatin to Deduce Function from Form
Marissa Fessenden | Dec 1, 2018
Researchers describe their tools for probing how the physical shape of the genome affects genes’ function.
New Techniques Detail Embryos’ First Hours and Days
Jef Akst | Dec 1, 2017
New technologies reveal the dynamic changes in mouse and human embryos during the first week after fertilization.
Infographic: How Embryos Take Control of Their Own Development
Jef Akst | Nov 30, 2017
The switch from maternal factors involves dynamic reprogramming of the zygotic genome.
Chromatin Conformation Computed
Anna Azvolinsky | Oct 19, 2015
By manipulating DNA sequences that guide genome-folding, researchers confirm an existing model of chromatin structure inside the nucleus.
Pushing the Limits
Marissa Fessenden | Feb 1, 2015
A guide to the newest techniques for examining epigenetics in single cells
Nuclear Cartography
Jeffrey M. Perkel | Oct 1, 2014
Techniques for mapping chromosome conformation
Karmella Haynes: Turning the Dials
Kerry Grens | Dec 1, 2013
Assistant Professor, Arizona State University. Age: 36