chromatin dynamics

In the mouse brain, nuclear RNAs can last for years with some of them potentially helping to maintain genome integrity.

Detailed analyses of cohesin’s movements indicate how this protein complex hauls chromatin fibers to package DNA into loops.

The hinge region of cohesin pulls DNA to two head regions, like a person’s hand-to-hand motion of pulling on a rope.

Genes lacking a particular structure known as CpG islands tend to go haywire in older cells, a study finds, potentially contributing to key facets of aging. But it’s not yet clear if the relationship is causal.

Hydra vulgaris constantly replenish the cells in their heads and grow new ones to reproduce asexually. But gene expression analyses reveal that regenerating a head after an injury is a very different process.

The Dana-Farber Cancer Institute researcher is developing cancer therapeutics based on how the physical structure of DNA contributes to the disease.

Researchers describe their tools for probing how the physical shape of the genome affects genes’ function.

New technologies reveal the dynamic changes in mouse and human embryos during the first week after fertilization.

The switch from maternal factors involves dynamic reprogramming of the zygotic genome.

By manipulating DNA sequences that guide genome-folding, researchers confirm an existing model of chromatin structure inside the nucleus.

A guide to the newest techniques for examining epigenetics in single cells

Techniques for mapping chromosome conformation

Assistant Professor, Arizona State University. Age: 36