chromatin structure

Detailed analyses of cohesin’s movements indicate how this protein complex hauls chromatin fibers to package DNA into loops.

The hinge region of cohesin pulls DNA to two head regions, like a person’s hand-to-hand motion of pulling on a rope.

Genes lacking a particular structure known as CpG islands tend to go haywire in older cells, a study finds, potentially contributing to key facets of aging. But it’s not yet clear if the relationship is causal.

The University of Oregon scientist studied the structure and function of chromatin, with the intent of designing new therapeutic tools.

The DNA-protein complex has branches that fold back on themselves.

Researchers describe their tools for probing how the physical shape of the genome affects genes’ function.

New technologies reveal the dynamic changes in mouse and human embryos during the first week after fertilization.

The switch from maternal factors involves dynamic reprogramming of the zygotic genome.

Recent data suggest that instead of folding into rigid higher-order structures, chromatin is malleable and diverse.

After initially discovering that DNA methylation represses transcription, Howard Cedar continues to explore how the epigenetic mark regulates gene expression.