ABOVE: Chromatin “tree” structure
NORTHWESTERN UNIVERSITY
Researchers have uncovered how chromatin, a mix of DNA and proteins that makes up chromosomes, folds at the molecular level. Chromatin is composed of branches that bend back on themselves and are spaced along a backbone, giving the structure gaps that allow it to be tightly packed, according to a study published in Science Advances last Friday (January 10).
A team co-led by Igal Szleifer and Vadim Backman, both biomedical engineers at Northwestern University, used mathematical modeling and microscopy to understand the 3-D structure of the genome of human cells at the nanoscale. They found that chromatin consists of tree-like domains of varying sizes, forming a “3D forest,” the study authors write. The complexity of this configuration suggests that chromatin has more organization and structural hierarchy than previously thought, which could help it avoid getting tangled.
“If genes are the hardware, chromatin is the software,” ...
