Vitamin D Deficiency Drives Opioid Addiction in Mice
Vitamin D Deficiency Drives Opioid Addiction in Mice
Mice with low vitamin D had exaggerated craving for opioids and felt the drugs’ effects more strongly—results supported in part by human medical records—suggesting that supplements should be explored as treatments for opioid use disorders.
Vitamin D Deficiency Drives Opioid Addiction in Mice
Vitamin D Deficiency Drives Opioid Addiction in Mice

Mice with low vitamin D had exaggerated craving for opioids and felt the drugs’ effects more strongly—results supported in part by human medical records—suggesting that supplements should be explored as treatments for opioid use disorders.

Mice with low vitamin D had exaggerated craving for opioids and felt the drugs’ effects more strongly—results supported in part by human medical records—suggesting that supplements should be explored as treatments for opioid use disorders.

clinical practice
Who Benefits from Herceptin and Other Anti-HER2 Cancer Therapies?
Who Benefits from Herceptin and Other Anti-HER2 Cancer Therapies?
Robert Fortner | Apr 12, 2020
Calls to include a new breast cancer subtype in future clinical trials reveal fundamental disagreements about HER2’s role in the disease.
Image of the Day: Spinal Tap
Image of the Day: Spinal Tap
Nicoletta Lanese | Aug 29, 2019
A medical art student’s master’s project will be used to help train junior physicians to perform lumbar punctures.
Drugs, Developed
Drugs, Developed
Bob Grant | Mar 1, 2019
In an era of instant communication, we must be careful how word of new and untested treatments is shared.
General Anesthesia Causes Telltale Brain Activity Patterns
General Anesthesia Causes Telltale Brain Activity Patterns
Emery N. Brown, Francisco J. Flores | Mar 1, 2019
The drugs lead to widespread, predictable changes in brain waves that can help anesthesiologists personalize anesthesia and develop anesthetic-based treatments.
Dartmouth Professor Plagiarized His Colleague, University Says
Dartmouth Professor Plagiarized His Colleague, University Says
Jef Akst | Aug 20, 2018
H. Gilbert Welch, a health policy expert who has advocated against superfluous cancer screening, published another Dartmouth researcher’s work, according to the university administration.
Exome Sequencing Helps Crack Rare Disease Diagnosis
Exome Sequencing Helps Crack Rare Disease Diagnosis
Amanda B. Keener | May 1, 2018
Clinical analyses of patients’ gene sequences are helping to provide answers where none were available before.
Sequencing Genomes in the ICU Improves Outcomes
Sequencing Genomes in the ICU Improves Outcomes
Bob Grant | Oct 19, 2017
A handful of infants in a neonatal intensive care unit who were diagnosed with rare diseases using whole-genome sequencing had shorter hospital stays and better health outcomes, researchers find.
Is Medicine Ready for Clinical CRISPR?
Is Medicine Ready for Clinical CRISPR?
John Parrington | Dec 1, 2016
Using precision genome editing to treat or prevent human disease may require several leaps of faith.
Book Excerpt from <em>Redesigning Life</em>
Book Excerpt from Redesigning Life
John Parrington | Nov 30, 2016
In Chapter 8, author John Parrington explores the intersection of precision genome editing and stem cell technologies.
The Upside
The Upside
Amanda B. Keener | Sep 1, 2015
Researchers explore the benefits of hearing loss and impairment.
New NIH IRB Guidelines Proposed
New NIH IRB Guidelines Proposed
Jef Akst | Dec 8, 2014
A draft policy from the US National Institutes of Health suggests that clinical studies performed at multiple sites should be reviewed by a single institutional review board.
Valuable Cord Blood Sits Unused
Valuable Cord Blood Sits Unused
Lydia Chain | Dec 5, 2014
High costs are keeping patients from using stem cells harvested from umbilical cords.
Exomes in the Clinic
Exomes in the Clinic
Tracy Vence | Oct 21, 2014
Two teams report molecular diagnosis rates of 25 percent sequencing separate sets of patients with undiagnosed, suspected genetic conditions.
NIH Expands Undiagnosed Diseases Program
NIH Expands Undiagnosed Diseases Program
Tracy Vence | Jul 3, 2014
The National Institutes of Health is funding six extramural medical centers to help identify the causes of mysterious diseases.
Vegetative States Probed with PET
Vegetative States Probed with PET
Bob Grant | Apr 17, 2014
Researchers find that positron emission tomography scans can help determine the degree to which some vegetative patients retain consciousness.
Opinion: Overcoming Cancer’s Complexities
Opinion: Overcoming Cancer’s Complexities
Daniel S. Kapp, David Rubenson, Beverly Mitchell | Apr 11, 2014
Considering “targeted therapeutics” in the face of intra-patient heterogeneity. 
The Dark Side of Curing Cancer
The Dark Side of Curing Cancer
Jef Akst | Apr 7, 2014
Panelists at AACR discuss the health risks that cancer survivors must face.
New Blood, circa 1914
New Blood, circa 1914
Jef Akst | Apr 1, 2014
World War I provided testing grounds for novel blood-transfusion techniques.
Week in Review: March 10–14
Week in Review: March 10–14
Tracy Vence | Mar 14, 2014
Whole-genome sequencing in the clinic; blood-based biomarkers predict future cognitive problems; how some pain meds inhibit bacterial growth; ResearchGate launches Open Review