Putative Exercise Hormone Irisin Boosts Mouse Brainpower
Putative Exercise Hormone Irisin Boosts Mouse Brainpower
Mice lacking irisin didn’t exhibit the cognition improvements that typically follow exercise, and in mouse models of Alzheimer’s disease, treatment with the hormone reduced cognitive decline.
Putative Exercise Hormone Irisin Boosts Mouse Brainpower
Putative Exercise Hormone Irisin Boosts Mouse Brainpower

Mice lacking irisin didn’t exhibit the cognition improvements that typically follow exercise, and in mouse models of Alzheimer’s disease, treatment with the hormone reduced cognitive decline.

Mice lacking irisin didn’t exhibit the cognition improvements that typically follow exercise, and in mouse models of Alzheimer’s disease, treatment with the hormone reduced cognitive decline.

cognitive decline
Dietary Spermidine Boosts Cognition in Insects and Rodents
Dietary Spermidine Boosts Cognition in Insects and Rodents
Ruth Williams | Apr 15, 2021
Mice and flies given the polyamine in their diet have increased brain cell metabolism and cognitive function, and epidemiological data hints at a similar benefit in humans.
Poor Sleep Linked with Future Amyloid-β Build Up
Poor Sleep Linked with Future Amyloid-β Build Up
Abby Olena | Sep 11, 2020
Accumulation of the protein was more likely to be found in the brains of people who slept less well years earlier, according to a new study.
Infographic: What Social Isolation Can Mean for the Brain
Infographic: What Social Isolation Can Mean for the Brain
Catherine Offord | Jul 13, 2020
People who show low social engagement over long periods of time often show reductions in cognitive function. Studies of the brain may provide clues about this correlation.
How Social Isolation Affects the Brain
How Social Isolation Affects the Brain
Catherine Offord | Jul 13, 2020
Absence of human contact is associated with declines in cognitive function. But as the COVID-19 pandemic brings concerns about the potential harms of isolation to the fore, researchers are still hunting for concrete evidence of a causal role as well as possible mechanisms.
Early Detection of Dementia with Smart Devices
Early Detection of Dementia with Smart Devices
Rachael Moeller Gorman | May 1, 2020
Digital biomarkers of cognitive decline could alert us to the early stages of dementia before irreversible damage occurs.
<em>APOE</em> Mutation Linked to Protection From Alzheimer&rsquo;s: Case Study
APOE Mutation Linked to Protection From Alzheimer’s: Case Study
Catherine Offord | Nov 5, 2019
A woman whose DNA suggested she’d develop early-onset dementia staved off cognitive decline for decades.
Genetic Risk for Alzheimer&rsquo;s Disease Linked to Highly Active Brains
Genetic Risk for Alzheimer’s Disease Linked to Highly Active Brains
Diana Kwon | Oct 1, 2019
A growing body of evidence supports the theory that neural hyperactivity and hyperconnectivity precede the pathological changes that lead to neurodegeneration.
Computers Extract Disease Clues from Speech
Computers Extract Disease Clues from Speech
Jef Akst | May 1, 2019
AI models can pick up subtle alterations in linguistic and vocal attributes of spoken language that may be indicative of failing health.
Young Blood Unproven as Anti-Aging Treatment: US FDA
Young Blood Unproven as Anti-Aging Treatment: US FDA
Carolyn Wilke | Feb 20, 2019
The agency warns that plasma treatments costing thousands of dollars, which supposedly treat the infirmities of old age, have not been proven “safe or effective.”
Air Pollution Linked to Decline in Cognitive Performance
Air Pollution Linked to Decline in Cognitive Performance
Shawna Williams | Aug 28, 2018
A study compares verbal and math test scores to air quality measurements in China and finds a correlation.
Researchers Develop Potential Blood Test for Alzheimer’s Disease
Researchers Develop Potential Blood Test for Alzheimer’s Disease
Catherine Offord | Feb 1, 2018
The test uses levels of plasma amyloid-β to estimate the buildup of protein plaques in the brain.
Equivocal Findings of Alzheimer’s Trial Using Young Blood
Equivocal Findings of Alzheimer’s Trial Using Young Blood
Catherine Offord | Nov 5, 2017
A team of Stanford University researchers say that administering young people’s blood plasma to Alzheimer’s patients could improve cognitive function, but the results have been criticized.
How Microbes May Influence Our Behavior
How Microbes May Influence Our Behavior
Amy Lewis | Sep 1, 2017
Researchers are piecing together the links between the gut microbiome and mental health.
Evidence Lacking for Brain-Training Products
Evidence Lacking for Brain-Training Products
Ben Andrew Henry | Oct 4, 2016
A literature review finds little evidence that commercial brain-training games can improve everyday cognitive performance, citing methodological shortcomings.
Immunotherapy for Alzheimer’s Disease Shows Promise
Immunotherapy for Alzheimer’s Disease Shows Promise
Alison F. Takemura | Aug 31, 2016
Biogen’s aducanumab reduces amyloid-β plaques in a dose-dependent manner, according to interim results of a Phase 1b clinical trial.
Cognitive Decline More Swift in Women
Cognitive Decline More Swift in Women
Kerry Grens | Jul 22, 2015
Mental agility in women deteriorates at twice the rate of that in men, according to a study of people with mild cognitive impairment.
Opinion: Can the Brain Be Trained?
Opinion: Can the Brain Be Trained?
Erin Abner | Mar 22, 2015
Online brain-training is gaining popularity, but so far little evidence exists to support claims of improved cognition.
NIDA Weighs In on Pot
NIDA Weighs In on Pot
Bob Grant | Jun 9, 2014
Addiction is one among many potential adverse effects of the increasingly popular drug, according to the National Institute on Drug Abuse.
Sex-Biased Alzheimer’s Variant
Sex-Biased Alzheimer’s Variant
Kerry Grens | Apr 14, 2014
Women with a notorious variant of a gene involved in Alzheimer’s, APOE4, are much more likely than men with the variant to develop the neurodegenerative disease.