A Challenge Trial for COVID-19 Would Not Be the First of Its Kind
A Challenge Trial for COVID-19 Would Not Be the First of Its Kind
Although scientists debate the ethics of deliberately infecting volunteers with SARS-CoV-2, plenty of consenting participants have been exposed to all sorts of pathogens in prior trials.
A Challenge Trial for COVID-19 Would Not Be the First of Its Kind
A Challenge Trial for COVID-19 Would Not Be the First of Its Kind

Although scientists debate the ethics of deliberately infecting volunteers with SARS-CoV-2, plenty of consenting participants have been exposed to all sorts of pathogens in prior trials.

Although scientists debate the ethics of deliberately infecting volunteers with SARS-CoV-2, plenty of consenting participants have been exposed to all sorts of pathogens in prior trials.

dengue infection
For the Greater Good: A Profile of Eva Harris
For the Greater Good: A Profile of Eva Harris
Diana Kwon | Jul 13, 2020
Through groundbreaking studies on dengue and efforts to build scientific infrastructure in Latin America, the University of California, Berkeley, professor has bridged research with its benefits to society.
Dengue Cases Drop After Bacteria-Infected Mosquitoes Released
Dengue Cases Drop After Bacteria-Infected Mosquitoes Released
Emily Makowski | Nov 22, 2019
Aedes aegypti infected with Wolbachia—which inhibit transmission of the dengue virus from insect to human—were deployed in Indonesia, Vietnam, Brazil, and Australia.
Past Dengue Infection Appears to Protect Children from Zika Symptoms
Past Dengue Infection Appears to Protect Children from Zika Symptoms
Carolyn Wilke | Jan 23, 2019
Children were 38 percent less likely to show signs of Zika infection if they had previously had dengue.
Antibiotics Increase Mouse Susceptibility to Dengue, West Nile, and Zika
Antibiotics Increase Mouse Susceptibility to Dengue, West Nile, and Zika
Shawna Williams | Mar 27, 2018
The drugs’ disruption of the microbiome makes a subsequent flavivirus infection more severe.
Dengue Vaccine Program Halted Over Safety Issues
Dengue Vaccine Program Halted Over Safety Issues
Shawna Williams | Dec 5, 2017
The drug may worsen future infections for people who haven't already been exposed to the virus.
Dengue Infection Impairs Immune Defense Against Zika
Dengue Infection Impairs Immune Defense Against Zika
Catherine Offord | Aug 18, 2017
A memory B cell response to Zika virus in dengue-infected patients produced antibodies that were poorly neutralizing in vitro and instead enhanced infection.
Anti-Flavivirus Antibodies Enhance Zika Infection in Mice
Anti-Flavivirus Antibodies Enhance Zika Infection in Mice
Anna Azvolinsky | Mar 30, 2017
Researchers report evidence of antibody-dependent enhancement in a Zika-infected, immunocompromised mouse model.
Zika and Dengue Immunity: A Complex Relationship
Zika and Dengue Immunity: A Complex Relationship
Amanda B. Keener | Jun 28, 2016
Researchers examine the blood of people infected with dengue virus, finding a few Zika-neutralizing antibodies among mostly enhancing ones.
Dengue Antibodies Enhance Zika Infection?
Dengue Antibodies Enhance Zika Infection?
Tanya Lewis | Apr 28, 2016
Previous flavivirus infection could help explain the severity of symptoms in some people infected during the ongoing Zika outbreak, researchers report.
Speaking of Science
Speaking of Science
The Scientist Staff | Mar 1, 2016
March 2016's selection of notable quotes
New Virus Discovered in Human Blood
New Virus Discovered in Human Blood
Jef Akst | Sep 23, 2015
Researchers identify a novel virus in blood samples taken in the 1970s.
Dengue’s Downfall?
Dengue’s Downfall?
Jef Akst | Sep 15, 2015
Researchers characterize a protein that could be key to the virus’s virulence—and to developing a vaccine against the mosquito-borne disease.
Dengue-Targeting T Cells Home to Skin
Dengue-Targeting T Cells Home to Skin
Jenny Rood | Mar 11, 2015
Immune cells specific for the virus are present in the skin of infected patients, a study shows.
New Dengue-Detecting Antibodies
New Dengue-Detecting Antibodies
Molly Sharlach | Dec 15, 2014
Researchers uncover a class of antibodies that may confer immunity to different serotypes of the dengue virus.
Antibody-Dependent Enhanced (ADE) Immunity
Antibody-Dependent Enhanced (ADE) Immunity
Beth Marie Mole | Mar 1, 2013
The method to the dengue virus's maddening infectiousness.
Tough Bugger
Tough Bugger
Megan Scudellari | Mar 1, 2013
Fearless cockroach hunter Coby Schal investigates how insects communicate via chemical cues, then subverts those signals for pest control.
Bedeviled by Dengue
Bedeviled by Dengue
Beth Marie Mole | Mar 1, 2013
The global spread of dengue virus has immunologists and public-health experts debating the best way to curb infection.
How Dengue Does It
How Dengue Does It
Beth Marie Mole | Feb 28, 2013
Dengue virus has sophisticated mechanisms for entering a cell, for replicating its RNA genome, and for transcribing proteins.