Red blood vessels that decrease in diameter as they radiate outward are pictured on a pink and white surface
Antisense Oligonucleotides Cross Rodents’ Blood-Brain Barrier
RNA-DNA complexes that were modified with cholesterol made it into the brains of rats and mice, where they knocked down target genes.
ABOVE: ISTOCK.COM, UGREEN
Antisense Oligonucleotides Cross Rodents’ Blood-Brain Barrier
Antisense Oligonucleotides Cross Rodents’ Blood-Brain Barrier

RNA-DNA complexes that were modified with cholesterol made it into the brains of rats and mice, where they knocked down target genes.

RNA-DNA complexes that were modified with cholesterol made it into the brains of rats and mice, where they knocked down target genes.

ABOVE: ISTOCK.COM, UGREEN

drug delivery systems

Infographic: Building Bacteria to Fight Cancer
Simone Schuerle, Tal Danino | Apr 1, 2020
Researchers are engineering microbes to deliver therapeutics specifically to tumors, maximizing the treatments’ efficacy while minimizing side effects.
Bacteria as Living Microrobots to Fight Cancer
Simone Schuerle, Tal Danino | Apr 1, 2020
Autonomous, living microrobots that seek and destroy cancer are not as futuristic as one might imagine, thanks to a fusion of robotics and synthetic biology.
Laser-Triggered Nanobubbles Blast a Path into Biofilms
Jonathan Wosen | Apr 1, 2020
Researchers could one day use the method to deliver antibiotics to topical wounds infected by hard-to-treat masses of bacteria.
smartphone controlled device implanted in mouse brain
Image of the Day: Smartphone-Controlled Brains
Nicoletta Lanese | Aug 7, 2019
A device implanted into mice can modulate brain circuit activity over long periods of time.
Microneedle patch delivers liquid medications
Image of the Day: Artificial Snake Bite
Nicoletta Lanese | Aug 6, 2019
A microneedle delivers liquid medicines through tiny, fang-like points.
DNA-Delivered Antibodies Fight Off Lethal Bacterial Infection
Catherine Offord | Oct 3, 2017
Mice receiving the treatment produced their own monoclonal antibodies and survived infection with the life-threatening pathogen Pseudomonas aeruginosa.
Tiny Motors Deliver Ulcer Medication in Mouse Stomachs
Shawna Williams | Aug 16, 2017
The mini machines treated infection somewhat better than antibiotics plus the typical proton pump inhibitor medication. 
Image of the Day: Teeny Tiny Delivery Balls
The Scientist Staff | Aug 3, 2017
Scientists designed autonomous nanovesicles capable of following glucose concentration gradients, even through the blood brain barrier in rats.