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zebrafish in an aquarium
Epigenetics May Remember Ancestors’ Mutations
Parents’ mutations, even if they’re not inherited by offspring, could affect subsequent generations through changes to epigenetic marks, a study finds.
Epigenetics May Remember Ancestors’ Mutations
Epigenetics May Remember Ancestors’ Mutations

Parents’ mutations, even if they’re not inherited by offspring, could affect subsequent generations through changes to epigenetic marks, a study finds.

Parents’ mutations, even if they’re not inherited by offspring, could affect subsequent generations through changes to epigenetic marks, a study finds.

epigenetic regulation
Illustration from the epigenetics and the genome infographic
Infographic: How Epigenetic Marks Can Change the Genome
Katarina Zimmer | Nov 1, 2022 | 2 min read
Although epigenetic changes were long thought to largely act on the genome, rather than as part of it, research is now showing that these patterns can, directly or indirectly, change the genetic code.
Cellular DNA and epigenetics
Do Epigenetic Changes Influence Evolution?
Katarina Zimmer | Nov 1, 2022 | 10+ min read
Evidence is mounting that epigenetic marks on DNA can influence future generations in a variety of ways. But how such phenomena might affect large-scale evolutionary processes is hotly debated.
white mouse sitting down
Drug Spurs Neuron Growth in Mice with Chronic Spinal Cord Injury
Natalia Mesa, PhD | Sep 27, 2022 | 4 min read
A protein duo increases transcription of growth-related genes to enhance axon regeneration and boost plasticity, a study finds—but fails to improve mobility.
Alcohol bottles at a bar
Epigenome Editing Decreases Alcohol Seeking and Anxiety in Rats
Natalia Mesa, PhD | May 20, 2022 | 4 min read
A CRISPR-based system that reverses epigenetic changes caused by adolescent binge drinking reduces adult addiction-like behaviors in rats, a study finds, suggesting that an epigenomic approach could someday help treat people with alcohol use disorder.
Abstract illustration of DNA
Signaling Dynamics Fine-Tune Gene Expression
Ruth Williams | Sep 3, 2021 | 3 min read
The dynamic behavior of a transcriptional activator can be used to specify the activity level of its target gene, a study suggests.
early-life stress, histone, chromatin, epigenetics, epigenetic modification, methylation, DNA, protein, stress, adversity, mice, genetics, genomics
Early-Life Stress Exerts Long-Lasting Effects Via Epigenome
Asher Jones | Mar 18, 2021 | 5 min read
In mice, epigenetic marks made on histones during infancy influence depression-like behavior during adulthood. A drug that reverses the genomic tags appears to undo the damage.
a mouse on an exercise wheel
Early Epigenetic Changes Regulate Voluntary Exercise in Mice: Study
Emma Yasinski | Dec 7, 2019 | 3 min read
Altering DNA methylation in a particular area of the hypothalamus halved the animals’ voluntary exercise as adults.
Researchers Engineer Epigenome Editors to Study How Gene Expression Affects Disease
Ashley Yeager | Jan 1, 2019 | 7 min read
Using CRISPR and other tools, scientists are modifying DNA methylation, histone marks, and other modifiers of gene expression to understand how they affect health and disease.
As Bees Specialize, So Does Their DNA Packaging
Shawna Williams | Sep 11, 2018 | 3 min read
A study of chemical tags on histone proteins hints at how the same genome can yield very different animals.
High-Throughput Epigenetics Analyses
Jyoti Madhusoodanan | Jan 1, 2018 | 7 min read
Emerging technologies help researchers draw mechanistic links between metabolism and epigenetic modification of DNA.
Scientists Look to Epigenetics to Thwart Viruses
Shawna Williams | Sep 1, 2017 | 5 min read
Some viral pathogens modify chromatin and other epigenetic machinery, making them appealing drug targets.
Plants’ Epigenetic Secrets
Jef Akst | Feb 1, 2017 | 10+ min read
Unlike animals, plants stably pass on their DNA methylomes from one generation to the next. The resulting gene silencing likely hides an abundance of phenotypic variation.
Infographic: Plant Methylation Basics
Jef Akst | Jan 31, 2017 | 2 min read
Multiple molecular mechanisms keep plant DNA methylation in order.
Researchers Grow “Frankenstein Ants” to Study Epigenetics
Jeffrey M. Perkel | Oct 1, 2016 | 4 min read
A molecular biologist ventures into entomology to use genetically modified ants as laboratory models of behavioral epigenetics.
Genes Expressed After Death
Tanya Lewis | Jun 23, 2016 | 1 min read
Understanding postmortem gene expression could help researchers improve organ transplants and time-of-death estimates, according to studies on mice and zebrafish.
Epigenetics of Obesity
Catherine Offord | Jan 28, 2016 | 2 min read
Differential expression of a chromatin-interacting protein is linked to weight variation in mice and humans, researchers show.
RNA Epigenetics
Gidi Rechavi, Chuan He, and Dan Dominissini | Jan 1, 2016 | 10 min read
DNA isn’t the only decorated nucleic acid in the cell. Modifications to RNA molecules are much more common and are critical for regulating diverse biological processes.
RNA Methylation Dynamics
and Gidi Rechavi, Dan Dominissini, and Chuan He | Dec 31, 2015 | 1 min read
Additions to the bases of RNA molecules can be written, read, and erased.
Opinion: Engineering the Epigenome
Anna Köferle, Stefan H. Stricker, and Stephan Beck | Aug 26, 2015 | 3 min read
The use of targetable chromatin modifiers has ushered in a new era of functional epigenomics.
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