genetic screens

Tumors contain thousands of genetic changes, but only a few are actually cancer-causing. A quicker way to identify these driver mutations could lead to more targeted cancer treatments.

Improving the reliability of genetic variant annotation and clinical interpretation

Trophoblasts, collected from the mother during a blood draw, can determine fetal genetic abnormalities currently diagnosed through amniocentesis or chorionic villi sampling.

US Preventive Services Task Force recommends genetic testing for mutations in the cancer-related genes for more—but not all—women.

Using a large CRISPR-based screen, researchers find possible genetic culprits for patients not having success with immune checkpoint inhibitors.  

Two freely available databases include data on hundreds of human cancer cell lines. 

Using the mutagenic chemical N-ethyl-N-nitrosourea, researchers confirm the role of a gene in a piglet deformity and identify potential models for human diseases. 

John Robertson was known for his contributions to reproductive medicine ethics and for solidifying the scholarly connection between biomedicine and law.

See how two new methods track responses to unique genetic manipulations in numerous individual cells in parallel.

Researchers have designed a screen to find unique molecules, called riboswitches, that determine whether transcription will proceed.

A newly developed method detects regulators of bacterial transcription called riboswitches.

Ever-improving CRISPR-based tools are already ripe for large-scale genetic screens.