New Technique Limits CRISPR-Cas9 Off-Target Mutations
New Technique Limits CRISPR-Cas9 Off-Target Mutations
A mouse study details a method called VIVO that predicts the accuracy of any guide RNA.
New Technique Limits CRISPR-Cas9 Off-Target Mutations
New Technique Limits CRISPR-Cas9 Off-Target Mutations

A mouse study details a method called VIVO that predicts the accuracy of any guide RNA.

A mouse study details a method called VIVO that predicts the accuracy of any guide RNA.

in vitro
Researchers Develop a Drug Against the Common Cold
Researchers Develop a Drug Against the Common Cold
Catherine Offord | May 15, 2018
In an in vitro study, the compound completely blocked the replication of rhinoviruses.
Colorblindness Study Reveals Unexpected Way to Make Blood Vessels
Colorblindness Study Reveals Unexpected Way to Make Blood Vessels
Ashley Yeager | May 1, 2018
Researchers stumbled across the connection while searching for ways to reduce vision problems in people with achromatopsia.
Image of the Day: Everybody Vomits
Image of the Day: Everybody Vomits
The Scientist Staff | Aug 31, 2017
In a process known as vomocytosis, macrophages swallow pathogens whole only to spew them back out later, unharmed.
Chloroquine Protects Against Zika In Vitro
Chloroquine Protects Against Zika In Vitro
Marcia Triunfol | May 12, 2016
The antimalarial drug reduces the number of infected Vero and human brain microvascular endothelial cells—among other cell types—in culture, researchers report in a preprint.
Next Generation: Toward Synthetic Neural Tissue
Next Generation: Toward Synthetic Neural Tissue
Catherine Offord | Apr 1, 2016
Scientists produce a tissue-like material containing hundreds of light-activated compartments that transmits an electrical signal when illuminated.
Antidepressant Exerts Epigenetic Changes
Antidepressant Exerts Epigenetic Changes
Anna Azvolinsky | Nov 25, 2015
Molecular markers could aid researchers’ assessment of patient response to the drug.
 
Organoid Biobank
Organoid Biobank
Kerry Grens | May 11, 2015
From the tissue of numerous colon cancer patients, researchers build 3-D cultures of tumors.
Seeded by Weeds
Seeded by Weeds
K. John Morrow Jr. | May 1, 2015
More than 50 years after cross-contamination of cultured cell lines was recognized, the problem continues to plague the scientific community.
Culturing Changes Cells
Culturing Changes Cells
Kerry Grens | Feb 3, 2015
Within days of their transfer to a dish, a certain epigenetic mark vanishes from mouse cells.