iPSC
Induced Pluripotent Stem Cells Show Signs of Donor Age
Induced Pluripotent Stem Cells Show Signs of Donor Age
Ashley P. Taylor | Dec 12, 2016
iPSCs created through the reprogramming of human somatic cells retain genomic marks of the donor’s age.
Studying “Stone Man Syndrome,” Scientists Inadvertently Improve Cellular Reprogramming
Studying “Stone Man Syndrome,” Scientists Inadvertently Improve Cellular Reprogramming
Ben Andrew Henry | Oct 25, 2016
While studying a rare genetic disease, researchers discovered a signaling pathway linked to the efficiency of reprogramming somatic cells into stem cells.
From Stem Cell to Oocyte In a Dish
From Stem Cell to Oocyte In a Dish
Anna Azvolinsky | Oct 17, 2016
For the first time, scientists generate functional mouse eggs from stem cells in culture.
Donor Stem Cells Improve Cardiac Function
Donor Stem Cells Improve Cardiac Function
Kerry Grens | Oct 12, 2016
After a heart attack, monkeys given induced pluripotent stem cell–derived cardiomyocytes show more regeneration in the organ, but with risks.
Stem Cells Made Waves in Biology and Medicine
Stem Cells Made Waves in Biology and Medicine
Karen Zusi | Oct 1, 2016
Since their introduction to the lab, pluripotent stem cells have gone from research tool to therapeutic, but the journey has been rocky.
Thirty Years of Progress
Thirty Years of Progress
The Scientist Staff | Oct 1, 2016
Since The Scientist published its first issue in October 1986, life-science research has transformed from a manual and often tedious task to a high-tech, largely automated process of unprecedented efficiency.
Toward Preventing Transplant Rejection with Immunologically Matched Stem Cells
Toward Preventing Transplant Rejection with Immunologically Matched Stem Cells
Ruth Williams | Sep 15, 2016
Matching the immunological characteristics of donor retinal cells to those of the recipient can reduce the chance of rejection.
Nailing Down HAR Function
Nailing Down HAR Function
Katherine S. Pollard | Jul 31, 2016
A remaining challenge in the study of human accelerated regions (HARs) is establishing their specific functions during development and other biological processes.
Stem Cells for Personalized Pain Therapy Testing
Stem Cells for Personalized Pain Therapy Testing
Anna Azvolinsky | Apr 21, 2016
Using patient-derived stem cells, researchers create laboratory neuron models that reflect a patient’s response to a pain drug.
Low Mutation Rate in iPSCs
Low Mutation Rate in iPSCs
Catherine Offord | Apr 11, 2016
The mutation rate in induced pluripotent stem cells is 10 times lower than in somatic cells, scientists show.