mental health

A large genome-wide association study in East Asians uncovers novel genetic links to depression, calling attention to the consequences of underrepresentation of non-European groups in genetic research data.

COVID-19 has killed more than 4 million people around the globe and has sickened many millions more. The neurological toll on those of us continuing to live through the pandemic may stretch years or decades into the uncertain future.

The Scientist spoke with Rachel Zeig-Owens, the director of epidemiology for the World Trade Center Health Program, about what scientists have learned after two decades of studying illness and disease among survivors.

The largest study of its kind identifies single nucleotide polymorphisms with disparate effects on men’s and women’s susceptibility to conditions such as bipolar disorder and schizophrenia.

A famous account of multiple personality disorder in the early 20th century foreshadowed a century of controversial diagnoses and debate among psychiatrists.

A study in people fails to detect differences in the brain’s response to fear or anxiety, long thought to be controlled by different neural circuits.

People who show low social engagement over long periods of time often show reductions in cognitive function. Studies of the brain may provide clues about this correlation.

Absence of human contact is associated with declines in cognitive function. But as the COVID-19 pandemic brings concerns about the potential harms of isolation to the fore, researchers are still hunting for concrete evidence of a causal role as well as possible mechanisms.

Those who had developed PTSD appear to be less able to suppress unwanted memories—traumatic or not—suggesting a role for the general ability to control memory recall in the disorder.

Studies point to a role for physical activity in fighting malignancies, improving treatment outcomes, and fostering overall health in patients.

Clues about the biological mechanisms that contribute to a person’s chance of contemplating or attempting suicide

The biochemical mechanisms in the brain underlying suicidal behavior are beginning to come to light, and researchers hope they could one day lead to better treatment and prevention strategies.

A meta-analysis of more than 80 studies from the past four decades finds weak evidence to support the use of medicinal cannabis to treat anxiety, depression, and other mental health disorders.

The effects of the therapy in a small group of  patients were long-lasting, researchers say, adding to evidence that the approach works for treatment-resistant depression.

The FDA has given the green light to the first major new classes of antidepressant therapies in decades, opening up new avenues for therapeutic development.

After a scientist at the National Microbiology Laboratory in Winnipeg had a mental breakdown that may have contributed to her death in 2016, employees raise red flags about an unhealthy work environment.

The facility, focused on finding treatments for mental health disorders, will be the first of its kind in the US.

Physical activity, independent of diet, shifts the composition of bacteria in the intestines, spurring researchers to search for species that might provide benefits akin to working out.

An external consultant will review the work environment of the institution’s Australian Centre for Ancient DNA, led by evolutionary molecular biologist Alan Cooper.