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Artist’s rendition of neural connections, with inactive neurons in the background
Ketamine Flips a “Switch” in Mice’s Brain Circuitry: Study
After injecting moderate doses of the dissociative anesthetic into the animals, previously “awake” brain cells go dark, and those that had been dormant suddenly light up.
Ketamine Flips a “Switch” in Mice’s Brain Circuitry: Study
Ketamine Flips a “Switch” in Mice’s Brain Circuitry: Study

After injecting moderate doses of the dissociative anesthetic into the animals, previously “awake” brain cells go dark, and those that had been dormant suddenly light up.

After injecting moderate doses of the dissociative anesthetic into the animals, previously “awake” brain cells go dark, and those that had been dormant suddenly light up.

mental health
crossword puzzle
Ten Minute Sabbatical
Emily Cox and Henry Rathvon | Dec 1, 2022 | 2 min read
Take a break from the bench to puzzle and peruse
magic mushrooms on a while background
Psilocybin Relieves Some Treatment-Resistant Depression Cases: Trial
Shawna Williams | Nov 3, 2022 | 2 min read
The research has caveats, including side effects and a lack of durability in the benefits of a single dose.
Leon Rosenberg in a grey sports coat
Physician and Geneticist Leon Rosenberg Dies at 89
Andy Carstens | Aug 3, 2022 | 3 min read
He advanced the field of medical genetics, spoke out about reducing the stigma associated with mental illness, and captured attention for asserting that scientific evidence failed to demonstrate that life begins at conception.
Shot of a young woman using a computer while working in a laboratory
Pandemic Amplifies Postdoc Struggles
Bianca Nogrady | Dec 28, 2021 | 9 min read
Postdoctoral fellows faced challenges before COVID-19 changed the way academia functions, and these early career scientists report that things have only gotten harder.
Colored Genetic Code DNA Molecule Structure stock photo
Genetic Risks for Depression Differ Between Ancestral Groups
Chloe Tenn | Oct 19, 2021 | 4 min read
A large genome-wide association study in East Asians uncovers novel genetic links to depression, calling attention to the consequences of underrepresentation of non-European groups in genetic research data.
Watercolour illustration of a figure
Our Aching Brains
Bob Grant | Oct 1, 2021 | 3 min read
COVID-19 has killed more than 4 million people around the globe and has sickened many millions more. The neurological toll on those of us continuing to live through the pandemic may stretch years or decades into the uncertain future.
Two emergency responders stand near a barricade on a street in New York
Q&A: Health of 9/11 First Responders 20 Years Later
Amanda Heidt | Sep 7, 2021 | 5 min read
The Scientist spoke with Rachel Zeig-Owens, the director of epidemiology for the World Trade Center Health Program, about what scientists have learned after two decades of studying illness and disease among survivors.
GWAS, psychotic disorder, mood disorder, Q&A, bipolar disorder, schizophrenia, depression, sex differences
Genetic Variants Tied to Sex Differences in Psychiatric Disorders
Amanda Heidt | Mar 31, 2021 | 5 min read
The largest study of its kind identifies single nucleotide polymorphisms with disparate effects on men’s and women’s susceptibility to conditions such as bipolar disorder and schizophrenia.
Identity Crisis, 1906
Catherine Offord | Mar 1, 2021 | 4 min read
A famous account of multiple personality disorder in the early 20th century foreshadowed a century of controversial diagnoses and debate among psychiatrists.
fear, anxiety, fMRI, study, neural circuits, brain study, neuroscience, amygdala, BNST
Brain Circuitry for Fear and Anxiety Is the Same on fMRI
Amanda Heidt | Sep 21, 2020 | 5 min read
A study in people fails to detect differences in the brain’s response to fear or anxiety, long thought to be controlled by different neural circuits.
Infographic: What Social Isolation Can Mean for the Brain
Catherine Offord | Jul 13, 2020 | 1 min read
People who show low social engagement over long periods of time often show reductions in cognitive function. Studies of the brain may provide clues about this correlation.
How Social Isolation Affects the Brain
Catherine Offord | Jul 13, 2020 | 10+ min read
Absence of human contact is associated with declines in cognitive function. But as the COVID-19 pandemic brings concerns about the potential harms of isolation to the fore, researchers are still hunting for concrete evidence of a causal role as well as possible mechanisms.
Study Probes Brain Activity in Survivors of Paris Terror Attacks
Jef Akst | May 1, 2020 | 5 min read
Those who had developed PTSD appear to be less able to suppress unwanted memories—traumatic or not—suggesting a role for the general ability to control memory recall in the disorder.
Regular Exercise Helps Patients Combat Cancer
Bente Klarlund Pedersen | Apr 1, 2020 | 10 min read
Studies point to a role for physical activity in fighting malignancies, improving treatment outcomes, and fostering overall health in patients.
Infographic: The Neurobiology of Suicidal Behavior
Catherine Offord | Jan 13, 2020 | 2 min read
Clues about the biological mechanisms that contribute to a person’s chance of contemplating or attempting suicide
What Neurobiology Can Tell Us About Suicide
Catherine Offord | Jan 13, 2020 | 10+ min read
The biochemical mechanisms in the brain underlying suicidal behavior are beginning to come to light, and researchers hope they could one day lead to better treatment and prevention strategies.
Value of Medical Marijuana for Mental Health Questioned
Jef Akst | Oct 29, 2019 | 2 min read
A meta-analysis of more than 80 studies from the past four decades finds weak evidence to support the use of medicinal cannabis to treat anxiety, depression, and other mental health disorders.
Deep Brain Stimulation Improves Depression Symptoms: Study
Catherine Offord | Oct 7, 2019 | 2 min read
The effects of the therapy in a small group of  patients were long-lasting, researchers say, adding to evidence that the approach works for treatment-resistant depression.
Antidepressant Approvals Could Herald New Era in Psychiatric Drugs
Bianca Nogrady | Oct 1, 2019 | 9 min read
The FDA has given the green light to the first major new classes of antidepressant therapies in decades, opening up new avenues for therapeutic development.
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