Modus Operandi
Phosphorylation at the Flick of a Switch
Phosphorylation at the Flick of a Switch
Ruth Williams | May 1, 2017
Incorporating light-controlled dimerization domains into kinases provides tight regulation of these enzymes.
Infographic: Enzymes Controlled by Light
Infographic: Enzymes Controlled by Light
Ruth Williams | Apr 30, 2017
Custom-designed kinases have built-in switches that act as gatekeepers for the enzymes' active sites.
Targeting Tregs Halts Cancer’s Immune Helpers
Targeting Tregs Halts Cancer’s Immune Helpers
Ruth Williams | Apr 1, 2017
New monoclonal antibodies kill both cancer-promoting immunosuppressive cells and tumor cells in culture.
Infographic: Antibody Cancer Therapy
Infographic: Antibody Cancer Therapy
Ruth Williams | Mar 31, 2017
An experimental technique removes T cells that aid in vitro tumor growth.
Massively Parallel Perturbations
Massively Parallel Perturbations
Ruth Williams | Mar 1, 2017
Scientists combine CRISPR gene editing with single-cell sequencing for genotype-phenotype screens.
Infographic: Single-Cell CRISPR Screens
Infographic: Single-Cell CRISPR Screens
Ruth Williams | Feb 28, 2017
See how two new methods track responses to unique genetic manipulations in numerous individual cells in parallel.
Deep Pocket Exploration
Deep Pocket Exploration
Ruth Williams | Feb 1, 2017
A modification to traditional docking software enables the examination of a ligand’s passage into its receptor.
Infographic: Modeling Molecules’ Receptor Binding
Infographic: Modeling Molecules’ Receptor Binding
Ruth Williams | Jan 31, 2017
A software upgrade follows ligands step-wise into their binding sites on receptors.
New Technique Enables Observation of Accessible Chromatin
New Technique Enables Observation of Accessible Chromatin
Ruth Williams | Jan 1, 2017
A test tube-based genome-labeling technique has been brought under the microscope.
Synthetic Sensors
Synthetic Sensors
Ruth Williams | Dec 1, 2016
Engineered circuits detect endogenous transcription factors to drive cellular outputs.