Custom-designed kinases have built-in switches that act as gatekeepers for the enzymes' active sites.

New monoclonal antibodies kill both cancer-promoting immunosuppressive cells and tumor cells in culture.

An experimental technique removes T cells that aid in vitro tumor growth.

Scientists combine CRISPR gene editing with single-cell sequencing for genotype-phenotype screens.

See how two new methods track responses to unique genetic manipulations in numerous individual cells in parallel.

A modification to traditional docking software enables the examination of a ligand’s passage into its receptor.

A software upgrade follows ligands step-wise into their binding sites on receptors.

A test tube-based genome-labeling technique has been brought under the microscope.

Engineered circuits detect endogenous transcription factors to drive cellular outputs.

Scientists designed a genetic sensor-and-readout system, based on detecting a transcription factor, that performs a custom cellular activity.